| 刘桂伟,任维聃,李泽钊,等.新斯的明穴位注射治疗老年结肠癌术后肠麻痹的疗效观察[J].安徽医药,2025,29(9):1891-1894. |
| 新斯的明穴位注射治疗老年结肠癌术后肠麻痹的疗效观察 |
| Observation on the therapeutic effect of acupoint injection of neostigmine on postoperative intestinal paralysis in elderly patients with colon cancer |
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| DOI：10.3969/j.issn.1009-6469.2025.09.041 |
| 中文关键词: 新斯的明 手术后并发症 穴位注射 结肠癌 术后肠麻痹 胃肠动力 肠道功能 |
| 英文关键词: Neostigmine Postoperative complications Acupoint injection Colon neoplasms Postoperative intestinal paraly-sis Gastrointestinal motility Intestinal function |
| 基金项目:河北省中医药管理局资助项目( 2021285) |
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| 中文摘要: |
| 目的分析新斯的明穴位注射治疗老年结肠癌术后肠麻痹( POI)的疗效。方法选取 2018年 11月至 2020年 4月沧州市中心医院收治的老年结肠癌 POI病人 98例，随机数字表法将其分为两组，对照组 49例给予常规治疗，观察组 49例在常规基础上给予双侧足三里新斯的明注射，比较两组病人临床疗效、肠道功能指标、胃肠动力指标及炎症因子。结果观察组治疗有效率高于对照组(97.96%比 81.63%，P<0.05)。与对照组［(57.26±4.02)h、(40.29±3.05)h、(12.47±1.21)h］相比，观察组首次排便［( 43.26±3.26)h］、排气时间［( 31.26±2.36)h］、肠鸣音恢复时间［( 8.64±1.02)h］较短( P<0.05)。与术前相比，术后 1d、7d，观察组血清炎症因子水平均有下降，且观察组低于对照组( P<0.05)。与术后 1d相比，术后 7d观察组血清唾液酸( SA)、铁蛋白(Fer)、胃动素( MTL)水平均低于对照组，胃泌素( GAS)水平高于对照组( P<0.05)。结论对老年结肠癌 POI病人采取新斯的明双侧足三里注射治疗，可显著改善病人胃肠功能，减轻炎症反应，可在临床上推广。 |
| 英文摘要: |
| Objective To analyze the therapeutic effect of acupoint injection of neostigmine on postoperative intestinal paralysis(POI) in elderly patients with colon cancer.Methods Ninety-eight elderly POI patients with colon cancer admitted to Cangzhou Cen-tral Hospital from November 2018 to April 2020 were selected as the research subjects and divided into two groups using random num-ber table. The control group (n=49) was given conventional treatment, while the observation group (n=49) received bilateral Zusanli neo-stigmine injection on the basis of the control group. The clinical efficacy, intestinal function indicators, gastrointestinal motility indica-tors, and inflammatory factors of the two groups of patients were compared.Results The effective rate of the observation group was higher than that of the control group (97.96% vs. 81.63%, P<0.05). Compared with the control group [(57.26±4.02) h, (40.29±3.05) h,(12.47±1.21) h], the observation group had shorter first defecation [(43.26±3.26) h] and exhaust time [(31.26±2.36) h] as well as bowelsound recovery time [(8.64±1.02) h] (P<0.05). Compared with preoperative, the serum inflammatory factor levels on the 1st and 7thdays after surgery in the observation group decreased, and those in the observation group was lower than those in the control group (P< 0.05). Compared with the postoperative day 1, the serum levels of sialic acid (SA), ferritin (Fer), and motilin (MTL) at day 7 in the obser-vation group were lower than those in the control group, while the levels of gastrin (GAS) were higher than those in the control group (P< 0.05).Conclusion Bilateral Zusanli injection of neostigmine can significantly improve gastrointestinal function and reduce inflamma-tory response in elderly patients with POI of colon cancer , which is worthy of clinical promotion. |
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