| 张秋惠,程洋洋.强心剂水方对肺源性心脏病心肺功能及缺氧诱导因子 -1α和血管内皮生长因子表达水平的影响[J].安徽医药,2025,29(9):1894-1898. |
| 强心剂水方对肺源性心脏病心肺功能及缺氧诱导因子 -1α和血管内皮生长因子表达水平的影响 |
| Effect of cardiotonic and diuretic therapy on cardiopulmonary function and expression levels of HIF-1α and VEGF in patients with pulmonary heart disease |
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| DOI：10.3969/j.issn.1009-6469.2025.09.042 |
| 中文关键词: 肺心病 强心剂水方 心肺功能 缺氧诱导因子 血管内皮生长因子 |
| 英文关键词: Pulmonary heart disease Tonic water prescription Cardiopulmonary function Hypoxia-inducing factor Vascular endothelial growth factor |
| 基金项目:廊坊市科学技术研究与发展计划项目( 2022013046) |
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| 中文摘要: |
| 目的探讨强心剂水方对肺源性心脏病(肺心病)心肺功能及缺氧诱导因子 -1α(HIF-1α)和血管内皮生长因子( VEGF)表达水平的影响。方法选取 2022年 1月至 2023年 6月廊坊市中医医院收治的肺心病病人 60例，按照随机数字表法分为对照组和观察组，均 30例。对照组予以常规西药 +安慰剂治疗，观察组在常规西药基础上予以自拟强心剂)方治疗。比较两组临床疗效、心肺功能及 HIF-1α和 VEGF表达水平。结果观察组治疗后总有效率 93.33%较对照组 70.00%高( P<0.05)；观察组治疗后左心室射血分数( LVEF)、每搏量( SV)、第 1秒用力呼气容积( FEV1)、 1秒率( FEV1/FVC)水平较对照组高、 6 min步行距离试验( 6MWD)较对照组远，平均肺动脉压(MPAP)、N-端脑利钠肽前体( NT-proBNP)水平较对照组低( P<0.05)；观察组治疗后 HIF-1α(252.87±81.36)ng/L和 VEGF(200.26±76.98)ng/L表达水平较对照组( 302.64±95.22)ng/L、(249.68±89.67)ng/L低( P<0.05)。结论强心剂水方能下调肺心病病人 HIF-1α、VEGF表达水平，改善心肺功能，疗效显著。 |
| 英文摘要: |
| Objective To explore the effects of cardiotonic and diuretic therapy on cardiopulmonary function, hypoxia-inducing fac-tor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression in patients with pulmonary heart disease (cor pulmonale). Methods Sixty patients with pulmonary heart disease admitted to Langfang Traditional Chinese Medicine Hospital from January 2022to June 2023 were selected and assigned into 2 groups according to random number table method, with 30 cases in both control groupand observation group. The control group was treated with conventional Western medicine plus placebo, and the observation group wastreated with self-prepared cardiotonic and diuretic therapy in addition to conventional Western medicine. The clinical efficacy, cardio-pulmonary function and expression levels of HIF-1α and VEGF were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (93.33% vs. 70.00%, P<0.05). After treatment, the left ventricularejection fraction (LVEF), stroke volume (SV), forced expiratory volume in the first second (FEV1) and forced expiratory volume in 1 sec-ond / forced vital capacity (FEV1 /FVC) in the observation group were higher than those in the control group, and the 6-minute walkingdistance test (6MWD) was longer than that in the control group. The mean pulmonary artery pressure (MPAP) and the level of N-termi-nal pro-brain natriuretic peptide precursor (NT-proBNP) were lower than those in the control group (P<0.05). After treatment, the ex-pression levels of HIF-1α and VEGFin the observation group were lower than those in the control group [(252.87±81.36) ng/L vs. (302.64±95.22) ng/L, (200.26±76.98) ng/L vs. (249.68±89.67) ng/L; P<0.05]. Conclusions The efficacy of cardiotonic and diuretic therapy is clinically significant. The expression levels of HIF-1α and VEGF in patients with pulmonary heart disease can be reduced and the cardiopulmonary function can be improved. |
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