| 杨长煌,郑德义.TOLL样受体 4参与糖尿病足溃疡机制研究进展[J].安徽医药,2025,29(10):1909-1913. |
| TOLL样受体 4参与糖尿病足溃疡机制研究进展 |
| Research progress on the role of TLR4 in the mechanism of diabetic foot ulcers |
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| DOI：10.3969/j.issn.1009-6469.2025.10.001 |
| 中文关键词: 糖尿病足溃疡: TOLL样受体 4 炎症反应 巨噬细胞 极化 血管生成 |
| 英文关键词: Diabetic foot ulcers Toll-like receptor 4 Inflammatory reaction Macrophage Polarization Angiogenesis |
| 基金项目:国家自然科学基金项目( 81760021) |
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| 摘要点击次数: 67 |
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| 中文摘要: |
| 糖尿病足溃疡( DFU)是糖尿病并发症中常见的临床难题，其治疗困难、复发率高，近年来的研究发现， TOLL样受体 4(TLR4)影响巨噬细胞的极化，倾向于促炎的 M1表型，抑制修复所需的 M2表型； TLR4的激活影响血管生成，导致伤口区域的血供不足。 TLR4及其信号通路活化在 DFU的发生及愈合过程中发挥重要作用，全面了解 TLR4在 DFU中的作用有望为改善 |
| 英文摘要: |
| Diabetic foot ulcers (DFU) are common and challenging clinical complications of diabetes, characterized by therapeuticchallenges and high recurrence rates. Recent studies have found that TOLL-like receptor 4 (TLR4) affects macrophage polarization, pro-moting the pro-inflammatory M1 phenotype while inhibiting the M2 phenotype necessary for repair. Activation of TLR4 also affects an-giogenesis, leading to inadequate blood supply in the wound area. The activation of TLR4 and its signaling pathways plays a criticalrole in the development and healing of diabetic foot ulcers. A comprehensive understanding of TLR4's role in DFU may provide new in-sights for improving treatment outcomes and enhancing the quality of life for diabetic patients. |
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