| 闫珍影,贺建霞.免疫检查点抑制剂相关免疫不良反应发病机制的研究进展[J].安徽医药,2025,29(10):1914-1918. |
| 免疫检查点抑制剂相关免疫不良反应发病机制的研究进展 |
| Research progress on the pathogenesis of immune-related adverse events associated with immune checkpoint inhibitors |
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| DOI：10.3969/j.issn.1009-6469.2025.10.002 |
| 中文关键词: 免疫检查点抑制剂 免疫相关不良反应 流行病学 发病机制 综述 |
| 英文关键词: Immune checkpoint inhibitors Immune-related adverse events Epidemiology Pathogenesis Review |
| 基金项目:山西省自然科学基金项目( 201901D111435) |
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| 中文摘要: |
| 免疫检查点抑制剂( immune checkpoint inhibitors，ICIs)作为肿瘤免疫治疗的革命性药物，在发挥抗肿瘤作用的同时，会攻击自身正常组织，引起一系列不良反应，称为免疫相关不良反应( immune-related adverse event，IrAEs)。大部分 IrAEs较轻也微，少数严重 IrAEs会使肿瘤免疫治疗复杂化，甚至停止免疫治疗影响病人治疗效果，因此，需要更好地了解 IrAEs的发病机制，为及早发现、及时处理 IrAEs提供扎实的理论基础。该研究旨在全面阐述 IrAEs的发病机制相关知识，为其临床应用和未来研究提供参考。 |
| 英文摘要: |
| Immune checkpoint inhibitors (ICIs), as a revolutionary drug for tumor immunotherapy, may attack normal tissues while ex-erting their anti-tumor effects, causing a series of immune-related adverse events (IrAEs). Most of the IrAEs are mild, and a small num-ber of severe IrAEs can complicate the tumor immunotherapy, and even stop the immunotherapy, affecting the treatment effect of pa-tients. Therefore, it is necessary to better understand the pathogenesis of IrAEs, so as to provide a solid theoretical basis for early detec-tion and timely treatment of IrAEs. The purpose of this article is to comprehensively elaborate the relevant knowledge of IrAEs patho-genesis, providing reference for its clinical application and future research. |
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