| 邹旭,彭国璇,雷安毅,等.细胞衰老视角下椎间盘退变机制的研究进展[J].安徽医药,2025,29(10):1926-1933. |
| 细胞衰老视角下椎间盘退变机制的研究进展 |
| Research progress on the mechanism of intervertebral disc degeneration from the perspective of cell senescence |
| |
| DOI：10.3969/j.issn.1009-6469.2025.10.004 |
| 中文关键词: 椎间盘退行性变 细胞衰老 髓核 纤维环 软骨终板 综述 |
| 英文关键词: Intervertebral disc degeneration Aging Nucleus pulposus Annulus fibrosus Cartilage endplate Review |
| 基金项目:国家自然科学基金项目(82360420)；贵州省科技计划项目(黔科合基础 -ZK〔2023〕一般 387；黔科合基础 -ZK〔2024〕一般 222)；贵州省卫生健康委科学技术基金项目(gzwkj2024-158)；贵州医科大学附属医院博士科研启动基金项目(gyfybskj-2023-07) |
|
| 摘要点击次数: 47 |
| 全文下载次数: 56 |
| 中文摘要: |
| 椎间盘退变( intervertebral disc degeneration，IVDD)是引起腰背痛及下肢活动受限最常见的退变性疾病。细胞衰老是指细胞逐渐失去分裂能力和功能的过程，可通过驱动髓核细胞、纤维环细胞及软骨终板细胞衰老推进 IVDD进程。逆转椎间盘相关细胞衰老进程极可能是改善 IVDD的有效措施，但截至目前其具体分子机制仍不详。因此，该研究拟对细胞衰老与 IVDD之间的关系进行综述，以期为 IVDD提供新的治疗策略。 |
| 英文摘要: |
| Intervertebral disc degeneration (IVDD) is the most common degenerative disease that causes low back pain and lower limbmovement limitation. Cell senescence refers to the process in which cells gradually lose their division ability and function. It can pro-mote the IVDD process by driving the senescence of nucleus pulposus cells, annulus fibrosus cells, and cartilaginous endplates cells.Reversing IVD-related cell senescence is likely an effective measure to improve IVDD, but its specific molecular mechanism is still un-known. Therefore, this article reviews the relationship between cell senescence and IVDD so as to provide new therapeutic strategies forIVDD. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
