| 罗雍航,廖文建,李育栋,等.中性粒细胞胞外陷阱在肾纤维化中的研究进展[J].安徽医药,2025,29(10):1950-1955. |
| 中性粒细胞胞外陷阱在肾纤维化中的研究进展 |
| Research progress of neutrophil extracellular traps in renal fibrosis |
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| DOI：10.3969/j.issn.1009-6469.2025.10.008 |
| 中文关键词: 肾硬化症 中性粒细胞胞外陷阱(NETs) 炎症 肌成纤维细胞 蛋白尿 |
| 英文关键词: Nephrosclerosis Neutrophil extracellular traps (NETs) Inflammation Myofibroblast Proteinuria |
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| 摘要点击次数: 41 |
| 全文下载次数: 45 |
| 中文摘要: |
| 中性粒细胞是一种先天免疫细胞，在炎症早期被募集到损伤组织内，产生促炎细胞因子，释放由脱氧核糖核酸和颗粒蛋白组成的网状结构，即中性粒细胞胞外陷阱( neutrophil extracellular traps，NETs)。 NETs具有潜在毒性，可导致肾小球损伤，激活自身免疫过程，诱导血管损伤，促进肾纤维化。多项研究的证据表明， NETs通过多种途径促进肌成纤维细胞形成，加重蛋白尿，并加速肾纤维化的进展。该研究总结了 NETs在肾纤维化进展中的作用及其机制，为今后临床延缓肾纤维化的治疗提供新思路和有力证据。 |
| 英文摘要: |
| Neutrophils, which are innate immune cells, are recruited into damaged tissues at the early stage of inflammation, produc-ing pro-inflammatory cytokines, releasing a network structure composed of deoxyribonucleic acid and granular proteins, namely neutro-phil extracellular traps (NETs). NETs have potential toxicity, which can lead to glomerular damage, activate autoimmune processes, in-duce vascular damage, and promote renal fibrosis. Evidence from multiple studies has shown that NETs promote myofibroblast forma-tion, aggravate proteinuria, and accelerate the progression of renal fibrosis through a variety of ways. This paper summarizes the roleand mechanism of NETs in the progression of renal fibrosis, providing novel insights and strong evidence for future clinical interven-tions to delay renal fibrosis. |
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