| 张逸飞,薛江豪,赵娜娜,等.RNA结合蛋白在心肌梗死中的研究进展[J].安徽医药,2025,29(10):1955-1962. |
| RNA结合蛋白在心肌梗死中的研究进展 |
| Research progress on RNA-binding proteins in myocardial infarction |
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| DOI：10.3969/j.issn.1009-6469.2025.10.009 |
| 中文关键词: RNA结合蛋白类 心肌梗死 可变剪接 转录后调控 转导蛋白 β样蛋白 2 |
| 英文关键词: RNA binding proteins Myocardial infarction Alternative splicing Post-transcriptional regulation Transducin beta-like 2 |
| 基金项目:山西省科技厅自然科学研究面上项目( 202103021224373) |
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| 摘要点击次数: 65 |
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| 中文摘要: |
| RNA结合蛋白( RNA binding protein，RBP)对心肌梗死(myocardial infarction，MI)具有重要影响，通过调节 RNA代谢中的多个关键环节发挥作用。 RBP参与 RNA的剪接、表达、亚细胞定位及其稳定性，这些基本功能使得 RBP在心脏的生理及病理状态下都至关重要。研究 RBP的主要技术包括 RNA免疫沉淀、交联免疫沉淀和 RNA pulldown等，有助于深入理解 RBP与 RNA之间的互作。在 MI的背景下， RBP可通过调节 mRNA的可变剪接、与非编码 RNA相互作用，以及影响 N6-甲基腺苷的修饰等来影响心肌细胞生存与心功能。此外，差异表达的 RBP可以作为 MI的潜在生物标志物和治疗靶点，为早期诊断和精准治疗提供了新的方向。 |
| 英文摘要: |
| RNA binding proteins (RBPs) have a significant impact on myocardial infarction (MI) by playing roles in various key pro-cesses of RNA metabolism. RBPs are involved in RNA splicing, expression, subcellular localization, and stability, making them crucialin both physiological and pathological states of the heart. Techniques such as RNA immunoprecipitation, crosslinking immunoprecipita-tion, and RNA pulldown are used to study RBPs, aiding in understanding RBP-RNA interactions in depth. In the context of MI, RBPscan affect cardiomyocyte survival and cardiac function through regulation of mRNA alternative splicing, interactions with non-coding RNAs, and influence on N6-methyladenosine modifications. Additionally, differentially expressed RBPs can serve as potential biomark-ers and therapeutic targets for MI, providing new directions for early diagnosis and precision therapy. |
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