| 李楠,李国胜.原发于结肠的肉瘤样恶性腹膜间皮瘤 1例[J].安徽医药,2025,29(11):2211-2213. |
| 原发于结肠的肉瘤样恶性腹膜间皮瘤 1例 |
| Case report of primary sarcomatoid malignant peritoneal mesothelioma originating in the colon |
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| DOI：10.3969/j.issn.1009-6469.2025.11.019 |
| 中文关键词: 腹膜恶性间皮瘤 肉瘤 结肠 免疫组织化学 钙视网膜蛋白 WT1基因 波形蛋白 根治性手术 |
| 英文关键词: Peritoneal malignant mesothelioma Sarcoma Colon Immunohistochemistry Calretinin WT1 gene Vimentin Radical surgery |
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| 中文摘要: |
| 目的总结原发于结肠的肉瘤样恶性腹膜间皮瘤诊治经验，提高诊疗水平。方法回顾贵州医科大学附属医院 2022年 6月 19日收治的 1例结肠肿物住院病人的一般情况、病史特征、临床表现、实验室检查及诊治结果，并进行综合分析。结果病人主诉左下腹隐痛 10余天，加重伴便血 3d，术后病理结合免疫组织化学及基因检测结果为肉瘤样恶性间皮瘤。原发于结肠的肉瘤样恶性腹膜间皮瘤无特异性临床表现， CT及钡剂灌肠等影像学检查可以看出肿瘤边界、有无腹水形成及转移征象，然而无法确诊。最终需结合术中过程及多中心对多个核心切片的免疫组织化学评估和评价结果确诊。结论原发于结肠的肉瘤样恶性腹膜间皮瘤罕见，临床症状及实验室检查无特异性，术后多个核心切片的免疫组织化学评估是确诊该病的主要方式，治疗上对于局限性的肉瘤样恶性腹膜间皮瘤仍以手术切除为主。 |
| 英文摘要: |
| Objective To summarize the experience in diagnosing and treating primary sarcomatoid malignant peritoneal mesothelio-ma originating in the colon to improve diagnostic and therapeutic outcomes.Methods The general condition, medical history, clinicalmanifestations, laboratory findings, and diagnosis and treatment results of a patient with a colonic mass admitted to the Affiliated Hospi-tal of Guizhou Medical University on June 19, 2022, were retrospectively reviewed and comprehensively analyzed.Results The pa-tient presented with a chief complaint of dull pain in the left lower abdomen for more than 10 days, aggravated with hematochezia for 3days. Postoperative pathology combined with immunohistochemistry and genetic testing confirmed sarcomatoid malignant mesothelio-ma. Primary sarcomatoid malignant peritoneal mesothelioma originating in the colon lacks specific clinical manifestations, and imagingexamination. Imaging examinations such as CT and barium enema can reveal tumor boundaries, presence of ascites, and signs of metas-tasis, but cannot definitively confirm the diagnosis. The final diagnosis requires a combination of the intraoperative findings and immu-nohistochemical assessment and evaluation of multiple core sections from multiple centers.Conclusions Primary sarcomatoid malig-nant peritoneal mesothelioma originating in the colon is rare, with nonspecific clinical symptoms and laboratory findings. Postoperative immunohistochemical evaluation of multiple core sections is the main form of confirming the diagnosis of this disease, and surgical re-section is the primary method for confirming the diagnosis. For localized sarcomatoid malignant peritoneal mesothelioma, surgical resec-tion remains the mainstay of treatment. |
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