| 张劼,苏衍进.血清趋化因子样受体 1、几丁质酶 1水平与妊娠糖尿病病人胰岛素抵抗的关系[J].安徽医药,2025,29(11):2291-2294. |
| 血清趋化因子样受体 1、几丁质酶 1水平与妊娠糖尿病病人胰岛素抵抗的关系 |
| Relationship between serum chemokine-like receptor 1 and chitinase 1 levels and insulin resistance in patients with gestational diabetes mellitus |
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| DOI：10.3969/j.issn.1009-6469.2025.11.037 |
| 中文关键词: 妊娠糖尿病 趋化因子样受体 1 几丁质酶 1 胰岛素抵抗 相关性 |
| 英文关键词: Gestational diabetes mellitus Chemokine like receptor 1 Chitinase 1 Insulin resistance Correlation |
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| 中文摘要: |
| 目的分析血清趋化因子样受体 1(CMKLR1)、几丁质酶 1(CHIT1)水平是否与妊娠糖尿病( GDM)病人胰岛素抵抗有关。方法选取 2019年 1月至 2022年 1月在咸阳市中心医院诊治的 204例 GDM孕妇作为研究组，另选取同期该院孕检健康孕妇 204例为健康组。血清 CMKLR1、CHIT1水平采用酶联免疫吸附分析( ELISA)测定；采用 Pearson法分析相关性； logistic回归分析 GDM的影响因素。结果研究组空腹血糖、餐后 30 min血糖、餐后 1h血糖、餐后 2h血糖、糖化血红蛋白、空腹胰岛素、餐后 30 min胰岛素、餐后 1h胰岛素、餐后 2h胰岛素、血清 CMKLR1［(53.02±10.64)μg/L］、 CHIT1［(2.26±0.64)μg/L］水平、稳态模型评估胰岛素抵抗指数( HOMA-IR)(4.12±1.13)显著高于健康组［( 32.18±7.59)μg/L、(0.75±0.21)μg/L、2.02±0.64］(均 P<0.05)，稳态模型评估胰岛 β细胞功能指数( HOMA-β)以及早期胰岛素分泌指数( △I30/△G30)显著低于健康组(均 P<0.05)。 Pearson相关性分析显示血清 CMKLR1与 CHIT1水平呈正相关( r=0.59，P<0.05)； CMKLR1、CHIT1与 HOMA-IR均呈正相关( r= 0.54、0.57，均 P<0.05)与 HOMA-β(r=-0.60-0.56)△I30/△G30(r=-0.61-0.62)均呈负相关(均 P<0.05)。根据 logistic回归分析， CMKLR1(OR=5.32，P=0.005)、 CHIT1(OR=3.16=0.001)是影响 GDM的危险因素( P<0.05)。结论 GDM病血清 CMKLR1、CHIT1水平显著升高，且与胰岛素抵抗密切相关。 |
| 英文摘要: |
| Objective To analyze the relationship between chemokine-like receptor 1 (CMKLR1) and chitinase 1 (CHIT1) and insu-lin resistance in patients with gestational diabetes mellitus (GDM).Methods A total of 204 pregnant women with GDM diagnosed andtreated at Xianyang Central Hospital from January 2019 to January 2022 were selected as the study group, and 204 healthy pregnantwomen who underwent prenatal examination during the same period were selected as the control group. Serum CMKLR1 and CHIT1levels were measured by enzyme-linked immunosorbent assay (ELISA). Correlations were analyzed using Pearson's method, and influ-encing factors for GDM were assessed by logistic regression analysis.Results The study group showed significantly higher levels of fasting blood glucose, 30-min postprandial blood glucose, 1-hour blood glucose, 2-hour blood glucose, glycated hemoglobin, fasting in-sulin, 30-minute postprandial insulin, 1-hour insulin, 2-hour insulin, serum CMKLR1 [(53.02±10.64) μg/L], CHIT1 [(2.26±0.64) μg/L], and homeostasis model assessment of insulin resistance index (HOMA-IR) (4.12±1.13) compared to the control group [(32.18±7.59) μg/L, (0.75±0.21) μg/L, 2.02±0.64] (all P<0.05). In contrast, the homeostasis model assessment of β-cell function (HOMA-β) and early insulin secretion index (△I30/△G30) were significantly lower in the study group (all P<0.05). Pearson correlation analysis revealed a positive correlation between serum CMKLR1 and CHIT1 levels (r=0.59, P<0.05). Additionally, CMKLR1 and CHIT1 levels were posi-tively correlated with HOMA-IR (r=0.54, 0.57, all P<0.05) but negatively correlated with HOMA-β(r=.0.60, .0.56), △I30/△G30 (r= . 0.61, . 0.62, all P<0.05). Logistic regression analysis identified CMKLR1 (OR=5.32, P=0.005) and CHIT1 (OR=3.16, P=0.001) as risk factors for GDM (P<0.05).Conclusion Serum levels of CMKLR1 and CHIT1 are significantly elevated in GDM patients and are closely associated with insulin resistance. |
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