| 吴俊桥,郝轶群,傅自力.线粒体在特发性炎性肌病中的作用[J].安徽医药,2025,29(12):2333-2337. |
| 线粒体在特发性炎性肌病中的作用 |
| Role of mitochondria in idiopathic inflammatory myopathy |
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| DOI：10.3969/j.issn.1009-6469.2025.12.001 |
| 中文关键词: 线粒体 肌炎 自身免疫疾病 三羧酸循环 细胞凋亡 铁死亡 炎性小体 信号转导和转录激活因子 物质代谢 |
| 英文关键词: Mitochondria Myositis Autoimmune disease Tricarboxylic acid cycle Apoptosis Iron death Inflammatory corpuscles Signal transduction and transcription activating factors Substance metabolism |
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| 中文摘要: |
| 特发性炎症性肌病(IIM)是以肌无力、肌痛等肌肉损害和皮疹、关节炎等为主要特征的一组自身免疫性疾病，包括皮肌炎、抗合成酶综合征( ASS)、免疫介，导坏死性肌病( IMNM)、散发性包涵体肌炎( IBM)、多肌炎 5种；目前尚无安全有效的治疗方法，其发病率也在逐年升高。 IIM的发病机制尚未完全清楚，但其发病与免疫炎症关系甚密。近年来逐渐研究发现线粒体与多种炎症过程相关，并可能通过参与炎性小体、细胞异常死亡和信号转导和转录激活因子( STATs)等途径参与 IIM的发病。该研究结合文献，综述线粒体在 IIM致病过程中的作用，试图为 IIM的治疗提供新的思路。 |
| 英文摘要: |
| Idiopathic inflammatory myopathy (IIM) is a group of autoimmune diseases characterized by muscle damage such as myas-thenia and myalgia, as well as rash and arthritis, including dermatomyositis (DM), anti-synthetase syndrome (ASS), immuno-mediated necrotizing myopathy (IMNM), sporadic inclusion body myositis (IBM) and polymyositis (PM). There is no safe and effective treatmentat present, and its incidence is increasing year by year. The pathogenesis of IIM is not completely clear, but its pathogenesis is closelyrelated to immune inflammation. In recent years, it has been gradually found that mitochondria are related to various inflammatory pro-cesses, which may be involved in the pathogenesis of IIM by participating in inflammatory corpuscles, aberrant cell death and signaltransducer and activator of transcription (STATs). Based on existing literature, the role of mitochondria in the pathogenesis of IIM is re-viewed in this paper in order to provide a new idea for the treatment of IIM. |
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