| 焦阳,张丽.喉咽反流病中不同反流物作用机制的研究进展[J].安徽医药,2025,29(12):2344-2348. |
| 喉咽反流病中不同反流物作用机制的研究进展 |
| Research progress on the mechanism of action of different reflux compounds in laryngeal reflux disease and the choice of therapeutic drugs |
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| DOI：10.3969/j.issn.1009-6469.2025.12.003 |
| 中文关键词: 喉咽反流 食管酸反流 质子泵抑制剂 食管 pH监测 反流物成分 作用机制 |
| 英文关键词: Laryngopharyngeal reflux Esophageal acid reflux Proton pump inhibitors Esophageal pH monitoring Reflux sub-stance Mechanism of action |
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| 中文摘要: |
| 喉咽反流病( LPRD)是指胃十二指肠内容物反流至喉咽、口咽甚至鼻咽，引起一系列症状和体征的总称。 LPRD的发病机制尚不确切。治疗上多以质子泵抑制剂( PPI)作为抗酸反流的首选药物，但对于以非酸反流为主的 LPRD，PPI服药后不能有效缓解临床症状。明确反流物的性质，了解各反流物造成下咽部黏膜损伤的作用机制，对确定个体化治疗方案具有重要意义。该研究就不同反流物在 LPRD发病机制中的作用机制的研究进展作一综述。 |
| 英文摘要: |
| Laryngopharyngeal reflux disease (LPRD) refers to the reflux of gastroduodenal contents into the larynx, oropharynx, andeven nasopharynx, causing a series of symptoms and signs. The pathogenesis of LPRD is not exact. Proton pump inhibitors (PPI) aremostly used as the preferred drug for acid reflux, but for LPRD with non-acid reflux as the main drug, PPI cannot effectively relieveclinical symptoms after taking drugs. It is of great significance to clarify the nature of reflux and understand the mechanism of action ofeach reflux to cause damage to the hypopharyngeal mucosa. This article reviews the research progress of the mechanism of action of dif-ferent reflux compounds in LPRD. |
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