| 葛小栋,崔娟娟,郑娜,等.固本益肠补虚法治疗对直肠前切除综合征的疗效[J].安徽医药,2025,29(12):2384-2388. |
| 固本益肠补虚法治疗对直肠前切除综合征的疗效 |
| Effect of Guben yichang supplementing deficiency therapy on anterior rectal resection syndrome complicated |
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| DOI：10.3969/j.issn.1009-6469.2025.12.011 |
| 中文关键词: 直肠切除术 手术后并发症 固本益肠补虚法 氧化应激 炎症 排便 直肠前切除综合征 |
| 英文关键词: Proctectomy Postoperative complications Guben yichang supplementing deficiency therapy Oxidative stress In-flammation Defecation Low anterior resection syndrom |
| 基金项目:河北省中医药类科学研究课题计划项目( 2024155) |
| 作者 | 单位 | E-mail | | 葛小栋 | 唐山市中医医院,肛肠科,河北唐山 063000 | | | 崔娟娟 | 唐山市中医医院,肛肠科,河北唐山 063000 | | | 郑娜 | 唐山市中医医院,肛肠科,河北唐山 063000 | | | 任国玲 | 丰润区人民医院疼痛科,河北唐山 064099 | | | 王森 | 唐山市中医医院,窥镜科,河北唐山 063000 | | | 陆庆革 | 唐山市中医医院,肛肠科,河北唐山 063000 | yplc514@163.com |
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| 中文摘要: |
| 目的探讨固本益肠补虚法对直肠前切除术并发直肠前切除综合征治疗的作用。方法前瞻性选取 2022年 1月至 2023年 6月于唐山市中医医院接受直肠前切除术治疗并发直肠前切除综合征的 120例病人，按随机数字表法分为对照组( 60例)与研究组( 60例)，对照组采用常规治疗，研究组在对照组基础上联合口服、灌肠固本益肠补虚法治疗，两组均治疗 8周，对比两组治疗前后中医证候评分、低位前切除综合征评分( LARS评分)、氧化应激指标［丙二醛、超氧化物歧化酶( SOD)］、炎症指标［肿瘤坏死因子 α(TNF-α)、白细胞介素 -6(IL-6)、白细胞介素 -17(IL-17)］、肛门压力指标，并统计两组治疗期间不良反应情况。结果研究组治疗 8周后中医证候评分比对照组低( P<0.05)；研究组治疗 8周后 LARS评分( 16.57±2.53)分低于对照组(19.18±2.39)分( P<0.05)；研究组治疗 8周后丙二醛( 5.01±1.35)mmol/L、TNF-α(3.15±0.94)μg/L、IL-6(21.39±6.72)μg/L、IL-17(16.83±7.14)μg/L水平低于对照组［( 5.96±1.28)mmol/L、(3.86±0.78)μg/L、(25.46±7.13)μg/L、(20.12±7.85)μg/L］， SOD水平(93.18±10.24)U/mL高于对照组( 86.75±12.61)U/mL(P<0.05)；研究组治疗 8周后肛管最大耐受容量、肛管最大静息压、直肠排便阈值比对照组高( P<0.05)；两组不良反应比较( 10.00%比 6.67%)，差异无统计学意义( P>0.05)。结论直肠前切除综合征病人采用固本益肠补虚法可通过平衡氧化应激和炎症的机制减轻肠道损伤，调节肛门压力指标，改善排便功能，且不会增加不良反应。 |
| 英文摘要: |
| Objective To explore the role of Guben yichang supplementing in the treatment of rectal proctamietomy complicated byrectal proctamietomy syndrome.Method Prospective selection was made of 120 patients who underwent anterior resection of the rec-tum and developed anterior resection syndrome at Tangshan Traditional Chinese Medicine Hospital from January 2022 to June 2023.They were randomly divided into a control group (60 cases) and a study group (60 cases) using a random number table method. The con-trol group received conventional treatment, and the study group received combined oral and enema Guben yichang supplementing defi-ciency therapy on the basis of the therapy in the control group. Both groups were treated for 8 weeks. TCM syndrome score, low anteriorresection syndrome score (LARS score), oxidative stress index [malondialdehyde (MDA), superoxide dismutase (SOD)], inflammatory in-dex [TNF-α), interleukin-6 (IL-6), interleukin-17 (IL-17)] and anal pressure were compared between the two groups before and aftertreatment. The adverse reactions of the two groups during treatment were analyzed.Results After 8 weeks of treatment, the TCM syn-drome score in the study group was lower than that in the control group (P<0.05). The LARS score in the study group after 8 weeks oftreatment (16.57±2.53) points was lower than that in the control group (19.18±2.39) points (P<0.05). After 8 weeks of treatment, the lev-els of malondialdehyde (5.01±1.35) mmol/L, TNF-α (3.15±0.94) μg/L, IL-6 (21.39±6.72) μg/L, and IL-17 (16.83±7.14) μg/L in thestudy group were lower than those in the control group [(5.96±1.28) mmol/L, (3.86±0.78) μg/L, (25.46±7.13) μg/L, (20.12±7.85) μg/L],while the SOD level (93.18±10.24) U/mL was higher than that in the control group (86.75±12.61) U/mL (P<0.05). After 8 weeks of treat-ment, the maximum tolerance capacity, the maximum resting pressure and the threshold of rectal defecation in the study group werehigher than those in the control group (P<0.05). There was no significant difference in adverse reactions between the two groups (10.00% vs. 6.67%) (P>0.05). Conclusion Guben yichang supplementing deficiency therapy can reduce intestinal injury, regulateanal pressure index and improve defecation function without increasing adverse reactions by balancing oxidative stress and inflamma-tion. |
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