| 邹菊英,崔姣,陆文洪,等.肛周坏死性筋膜炎 52例的临床及病原学特征分析[J].安徽医药,2025,29(12):2412-2415. |
| 肛周坏死性筋膜炎 52例的临床及病原学特征分析 |
| Clinical and pathogenic characteristics analysis of 52 cases of perianal necrotizing fasciitis |
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| DOI：10.3969/j.issn.1009-6469.2025.12.017 |
| 中文关键词: 筋膜炎，坏死性 肛门 病原菌 耐药性 抗菌药物 临床特征 |
| 英文关键词: Fasciitis, necrotizing Anus Pathogen Drug resistance Antimicrobial agents Clinical characteristics |
| 基金项目:湖南省中医重点专科建设项目—中药学(湘中医药函〔 2023〕4号)；湖南省“十四五”中医药科技创新平台中医防治肛肠疾病临床研究中心项目(湘中医药函〔 2022〕93号)；湖南中医药大学校级科研基金项目( 2020XJJJ057) |
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| 中文摘要: |
| 目的分析肛周坏死性筋膜炎病人的临床及病原学特征。方法回顾性分析湖南中医药大学第二附属医院 2019— 2023年肛周坏死性筋膜炎 52例的临床资料和病原菌培养结果。结果纳入 52例肛周坏死性筋膜炎有病原学资料的病人，其中男性 45例( 86.53%)；年龄(51.98±16.59)岁， 50岁及以上占比 65.38%；所有病人均合并基础疾病。共分离出病原菌 54株，括革兰阴性菌 37株( 68.52%)，其中大肠埃希菌比例最高，革兰阳性菌 27.78%(15/54)，真菌 3.70%(2/54)。主要革兰阴性菌对包美罗培南、阿米卡星、替加环素及黏菌素等敏感率较高。主要革兰阳性菌对大部分抗菌药物均比较敏感。结论肛周坏死性筋膜炎是临床较为少见的疾病，其主要发生于中老年男性，主要病原菌是大肠埃希菌、肺炎克雷伯菌以及链球菌属。 |
| 英文摘要: |
| Objective To investigate the clinical characteristics and pathogenic features of perianal necrotizing fasciitis patients (PNF).Methods A retrospective analysis was performed on the clinical data and pathogenic culture results of 52 cases with perinealnecrotizing fasciitis at the Second Affiliated Hospital of Hu'nan University of Chinese Medicine from 2019 to 2023.Results A total of 52 patients with perianal necrotizing fasciitis and available pathogen data were enrolled, of whom 45 were males (86.53%). The averageage was (51.98±16.59), and 65.38% were 50 years old and over. All patients had underlying medical conditions. A total of 54 strains ofpathogenic bacteria were isolated, including 37 strains (68.52%) of Gram-negative bacteria, with the highest proportion of Escherichia coli, 27.78% (15/54) of Gram-positive bacteria, and 3.70% (2/54) of fungi. The main gram-negative bacteria had a high susceptibility rate to meropenem, amikacin, tigecycline and colistin. The main gram-positive bacteria were susceptible to most antimicrobial agents. Conclusion Perianal necrotizing fasciitis is a rare clinical disease, which mainly occurs in middle-aged and elderly men, and the main pathogens are Escherichia coli, Klebsiella pneumoniae and Streptococcus spp. |
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