| 陈虹,姜俊,朱薇,等.免疫球蛋白 A肾病伴高尿酸血症病人影响因素分析[J].安徽医药,2025,29(12):2422-2426. |
| 免疫球蛋白 A肾病伴高尿酸血症病人影响因素分析 |
| Risk factors for hyperuricemia in patients with immunoglobulin A nephropathy |
| |
| DOI：10.3969/j.issn.1009-6469.2025.12.019 |
| 中文关键词: IgA肾病 免疫球蛋白 A 高尿酸血症 男性 身体质量指数 肾小球滤过率 |
| 英文关键词: IgA nephropathy Immunoglobulin A Hyperuricemia Male sex Body mass index Glomerular filtration rate |
| 基金项目:中国初级卫生保健基金会肾病医学发展科研基金项目( 2022KY114) |
|
| 摘要点击次数: 551 |
| 全文下载次数: 286 |
| 中文摘要: |
| 目的分析免疫球蛋白( Ig)A肾病伴高尿酸血症病人的影响因素。方法选取 2020年 8月至 2023年 3月中国科学技术大学附属第一医院收治的 280例经肾穿刺活检明确诊断为 IgA肾病病人，按病人血尿酸水平分为两组，高尿酸组( n=101)及正常尿酸组( n=179)；采用 logistic回归方法探讨 IgA肾病伴高尿酸血症的影响因素。结果 280例 IgA肾病中高尿酸血症的患病率为 36.1%。IgA肾病伴高尿酸血症组身体质量指数( BMI)［25.11(23.21，27.56)kg/m2比 23.36(20.83，25.34)kg/m2］、平均动脉压［ 106.00(95.00，111.50)mmHg比 100.00(93.00，109.00)mmHg］(1 mmHg=0.133 kPa)高于正常尿酸组( P<0.05)两组在年龄方面比较差异无统计学意义( P>0.05)； IgA肾病高尿酸血症组血肌酐［ 100.00(85.20，135.50)μmol/L比 73.00(57.，00，92.70) μmol/L］、尿素氮［ 7.20(5.50，8.74)mmol/L比 5.57(4.40，6.40)mmol/L］、甘油三酯［ 1.91(1.35，2.85)mmol/L比 1.40(1.02，1.87) mmol/L］高于正常尿酸组，肾小球滤过率( GFR)［( 71.44±30.78)mL·min.1·(1.73 m2).1比( 96.80±37.82)mL·min.1·(1.73 m2).1］低于正常尿酸组( P<0.05)；而两组病人 24 h尿蛋白定量、白蛋白、血清 IgA、血清 IgG、血清 IgM、补体 C3、补体 C4、胆固醇、尿红细胞计数比较差异无统计学意义( P>0.05)；在慢性肾脏病(CKD)分期方面，高尿酸血症组临床分期更大( P<0.05)；在病理分级方面，高尿酸组病理分级更重( P<0.05)。多因素 logistic回归分析结果提示:男性、 BMI、GFR是 IgA肾病伴高尿酸血症病人的影响因素( P<0.05)BMI每增加 1个单位，风险增加 1.13倍， GFR每升高 1个单位，高尿酸血症的发生率降低 2.4%。结论男性、 BMI、GFR是 IgA肾，病伴高尿酸血症病人的影响因素。 |
| 英文摘要: |
| Objective To analyze the influencing factors for hyperuricemia in patients with immunoglobulin A (IgA) nephropathy. Methods A total of 280 patients with biopsy-proven IgA nephropathy admitted to The First Affiliated Hospital of the University ofScience and Technology of China from August 2020 to March 2023 were enrolled. According to serum uric acid levels, patients were as-signed into a hyperuricemia group (n = 101) and a normouricemia group (n = 179). Logistic regression analysis was performed to identi-fy factors associated with hyperuricemia in patients with IgA nephropathy.Results The prevalence of hyperuricemia in IgA nephropa-thy patients was 36.1%. Compared with the normouricemia group, patients in the hyperuricemia group had a higher body mass index(BMI) [25.11 (23.21, 27.56) kg/m2 vs. 23.36 (20.83, 25.34) kg/m2] and mean arterial pressure [106.00 (95.00, 111.50) mmHg vs. 100.00 (93.00, 109.00) mmHg] (1 mmHg=0.133 kPa) (P < 0.05), while there was no significant difference in age (P>0.05). Serum creatinine [100.00 (85.20, 135.50) μmol/L vs. 73.00 (57.00, 92.70) μmol/L], blood urea nitrogen [7.20 (5.50, 8.74) mmol/L vs. 5.57 (4.40, 6.40) mmol/L], and triglycerides [1.91 (1.35, 2.85) mmol/L vs. 1.40 (1.02, 1.87) mmol/L] were higher in the hyperuricemia group, whereas theestimated glomerular filtration rate (GFR) was lower [(71.44 ± 30.78) mL·min.1·(1.73 m2).1 vs. (96.80 ± 37.82) mL·min.1·(1.73 m2).1] (P<0.05). No significant differences were observed between the two groups in 24-hour urinary protein excretion, serum albumin, serumIgA, IgG, IgM, complement C3, complement C4, cholesterol, or urinary red blood cell count (P>0.05). Regarding chronic kidney dis-ease (CKD) stage and pathological grading, the hyperuricemia group presented with more advanced stages and more severe pathologicalgrades (P<0.05). Multivariate logistic regression analysis revealed that male, BMI, and GFR were independent risk factors for hyperuri-cemia in patients with IgA nephropathy (P<0.05). For each 1-unit increase in BMI, the risk increased by 1.13-fold, whereas each 1-unit increase in GFR was associated with a 2.4% reduction in hyperuricemia risk.Conclusion Male, BMI, and GFR are key factors influ-encing the occurrence of hyperuricemia in patients with IgA nephropathy. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
