| 代杰,张素响,赵沙沙,等.SIRT6、SIRT7联合 NIHSS评分对急性脑卒中病人静脉溶栓后长期预后的预测价值[J].安徽医药,2025,29(12):2507-2511. |
| SIRT6、SIRT7联合 NIHSS评分对急性脑卒中病人静脉溶栓后长期预后的预测价值 |
| Predictive value of SIRT6, SIRT7 combined with NIHSS score for long-term prognosis in acute stroke patients after intravenous thrombolysis |
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| DOI：10.3969/j.issn.1009-6469.2025.12.038 |
| 中文关键词: 脑梗死 溶栓治疗 卒中 沉默信息调节因子 6 沉默信息调节因子 7 美国国立卫生研究院卒中量表 预后 |
| 英文关键词: Brain infarction Thrombolytic therapy Stroke Silent information regulator 6 Silent information regulator 7 Na-tional institutes of health stroke scale Prognosis |
| 基金项目:河北省医学科学研究课题计划项目( 20200336) |
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| 中文摘要: |
| 目的研究沉默信息调节因子 6(SIRT6)、沉默信息调节因子 7(SIRT7)联合美国国立卫生研究院卒中量表( NIHSS)评分预测急性缺血性脑卒中( AIS)病人长期预后的价值。方法前瞻性选取 2020年 6月至 2023年 3月于沧州市中心医院治疗的 155例 AIS病人作为研究对象，将病人分为预后不良组( 57例)与预后良好组( 98例)。采用酶联免疫吸附分析( ELISA)检测血清 SIRT6、SIRT7水平。结果预后不良组 NIHSS评分 17.00(8.00，24.00)分、年龄( 76.82±7.05)岁、发病至溶栓时间( 5.07±0.54) h、大面积梗死病人比例( 64.91%)均高于预后良好组［ 6.00(3.00，9.00)分，(69.54±6.78)岁，(3.09±0.49)h，28.57%］血清 SIRT6 |
| 英文摘要: |
| Objective To explore the value of SIRT6 and SIRT7 combined with the National Institutes of Health Stroke Scale (NI-HSS) score in predicting long-term prognosis in patients with acute ischemic stroke (AIS).Methods A total of 155 AIS patients treatedin Cangzhou Central Hospital from June 2020 to March 2023 were prospectively selected as the study subjects, who were assigned into poor prognosis group (57 cases) and good prognosis group (98 cases). The baseline data of patients were recorded at admission. Enzyme-linked immunosorbent assay (ELISA) was applied to detect serum levels of SIRT6 and SIRT7.Results The NIHSS score 17.00 (8.00,24.00) points, age (76.82 ± 7.05) years old, time from onset to thrombolysis (5.07±0.54) h, and proportion of patients with large area in-farction (64.91%) in the poor prognosis group were higher than those in the good prognosis group [6.00 (3.00, 9.00) points, (69.54±6.78)years old, (3.09±0.49) h, 28.57%], while the levels of serum SIRT6 (4.86±1.02) μg/L and SIRT7 (32.78±9.45) ng/L were lower thanthose in the good prognosis group [(7.03±1.92) μg/L, (48.42±11.86) ng/L] (P<0.05). The AUC for predicting poor prognosis with serumSIRT6, SIRT7, and NIHSS scores alone and in combination was 0.84, 0.81, 0.87, and 0.93, respectively. The high NIHSS score was anindependent risk factor for poor prognosis in AIS patients after intravenous thrombolysis, while SIRT6 and SIRT7 were protective fac-tors (P<0.05).Conclusion The combination of pre-treatment serum SIRT6, SIRT7 levels, and NIHSS score can serve as effective pre-dictive indicators for long-term prognosis in AIS patients after intravenous thrombolysis. |
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