| 毛一凡,宰欣雨,陈仪泽,等.磷脂酰肌醇 3激酶 /蛋白激酶 B信号通路调控炎症因子在白内障发病机制中的研究进展[J].安徽医药,2026,30(1):1-5. |
| 磷脂酰肌醇 3激酶 /蛋白激酶 B信号通路调控炎症因子在白内障发病机制中的研究进展 |
| Research progress on the regulation of inflammatory factors by the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway in the pathogenesis of cataract |
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| DOI：10.3969/j.issn.1009-6469.2026.01.001 |
| 中文关键词: 白内障 磷脂酰肌醇 3激酶 蛋白激酶 B 发病机制 炎症因子 |
| 英文关键词: Cataract Phosphatidylinositol 3-kinase Kinase protein kinase B Pathogenesis Inflammatory factors |
| 基金项目:国家自然科学基金项目( 81960179) |
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| 中文摘要: |
| 白内障是眼睛晶状体发生混浊，导致光线无法正常透过，从而影响视力的临床常见眼病，也是导致失明的主要原因之一。磷脂酰肌醇 3激酶 /蛋白激酶 B(PI3K/Akt)信号通路调控炎症因子在细胞增殖、分化和蛋白合成过程中发挥重要作用，与多种疾病关系密切，该研究就 PI3K/Akt信号通路调控炎症因子在白内障发病机制中的研究进展作一综述。 |
| 英文摘要: |
| Cataract is a common clinical eye disease in which the lens of the eye becomes cloudy, preventing light from passingthrough normally and thus affecting vision. It is also one of the main causes of blindness. Regulation of inflammatory factors by thephosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway plays a significant role in cell proliferation, differentia-tion, and protein synthesis, and is closely related to various diseases. This study reviews the research progress of the PI3K/Akt signalingpathway regulating inflammatory factors in the pathogenesis of cataract. |
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