| 徐立君,张冰琰,史晋宇,等.外泌体在乳腺癌中的作用机制及应用前景[J].安徽医药,2026,30(1):6-11. |
| 外泌体在乳腺癌中的作用机制及应用前景 |
| Mechanism and application prospect of exosomes in breast cancer |
| |
| DOI：10.3969/j.issn.1009-6469.2026.01.002 |
| 中文关键词: 外泌体 乳腺肿瘤 细胞间通信 细胞外囊泡 肿瘤微环境 |
| 英文关键词: Exosomes Breast neoplasms Intercellular communication Extracellular vesicles Tumor microenvironment |
| 基金项目:山西省自然科学基金项目( 201901D111428) |
| 作者 | 单位 | E-mail | | 徐立君 | 山西医科大学第五临床医学院,山西太原03,0000
山西省人民医院乳腺外科,山西太原 030000 | | | 张冰琰 | 山西医科大学第五临床医学院,山西太原03,0000
山西省人民医院乳腺外科,山西太原 030000 | | | 史晋宇 | 山西医科大学第五临床医学院,山西太原03,0000
山西省人民医院乳腺外科,山西太原 030000 | | | 张亚芬 | 山西医科大学第五临床医学院,山西太原03,0000
山西省人民医院乳腺外科,山西太原 030000 | cocoren2005@163.com |
|
| 摘要点击次数: 563 |
| 全文下载次数: 221 |
| 中文摘要: |
| 乳腺癌是世界范围内女性最常见的恶性肿瘤，其发病率呈逐年上升趋势。外泌体属于细胞外囊泡的一个亚类，其携带各种活性物质介导细胞通信。近年来，许多研究表明，外泌体能够介导乳腺癌病程中血管新生、上皮 -间充质转化( epithelial-mesenchymal transition，EMT)、免疫调控以及耐药性获得的过程。此外，外泌体有潜力成为乳腺癌新的生物标志物和药物递送载体，为临床诊治乳腺癌提供新思路。该研究就外泌体在乳腺癌发生发展中的作用机制及应用前景进行综述。随着人们对外泌体的深入研究，将有助于乳腺癌的早期诊断、风险预测及个性化治疗。 |
| 英文摘要: |
| Breast cancer (BC) is the most common malignant tumor for women around the world, and its incidence is increasing yearby year. Exosomes belong to a subclass of extracellular vesicles that carry various active substances that mediate cell communication.In recent years, many studies have shown that exosomes can mediate angiogenesis, epithelial-mesenchymal transition (EMT), immuneregulation and the acquisition of drug resistance in the course of BC. In addition, exosomes have the potential to become new biomark-ers and drug delivery carriers of BC, providing new ideas for clinical diagnosis and treatment of BC. This study reviews the mechanismand application prospects of exosomes in the occurrence and development of BC. With the in-depth research on exosomes, it will be helpful for the early diagnosis, risk prediction and personalized treatment of BC. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
