| 陶菁,高悦.伏诺拉生联合阿莫西林根除幽门螺杆菌的研究进展[J].安徽医药,2026,30(1):16-21. |
| 伏诺拉生联合阿莫西林根除幽门螺杆菌的研究进展 |
| Research progress in the dual therapy with vonoprazan and amoxicillin for the eradication of H. pylori |
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| DOI：10.3969/j.issn.1009-6469.2026.01.004 |
| 中文关键词: 伏诺拉生 阿莫西林 质子泵抑制剂 幽门螺杆菌 胃肠疾病 |
| 英文关键词: Vonoprazan Amoxicillin Proton pump inhibitors Helicobacter pylori Gastrointestinal diseases |
| 基金项目:上海市临床药学重点专科建设项目(区属)(沪卫计药政〔2018〕9号) |
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| 中文摘要: |
| 幽门螺杆菌可感染胃黏膜，引起慢性炎症，导致包括胃癌在内的多种疾病。所有感染的幽门螺杆菌都建议根除，但是幽门螺杆菌的耐药性不断增加，根除率随之下降。伏诺拉生是一种钾竞争酸阻滞剂，比质子泵抑制剂产生更强的酸抑制作用。与三联和四联疗法相比，伏诺拉生和阿莫西林联合疗法达到了足够的根除率，降低了不良事件的风险。因此，近年来，伏诺拉生和阿莫西林二联疗法被认为是一种有效的幽门螺杆菌的根治方案。 |
| 英文摘要: |
| Helicobacter pylori can infect the gastric mucosa and cause chronic inflammation, resulting in various diseases, includinggastric cancer. Eradication of H. pylori in all infected subjects is recommended. However, the number of H. pylori strains with antibiotic resistance has increased, and the eradication rate has decreased. Vonoprazan, a potassium-competitive acid blocker, produces a stron-ger acid-inhibitory effect than proton pump inhibitors. The dual vonoprazan and amoxicillin therapy attains the sufficient eradicationrate with lowering the risk of adverse events in comparison with the triple therapy and quadruple therapy. Therefore, recently the dualvonoprazan and amoxicillin therapy is considered a useful eradication regimen for H.pylori infection. |
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