| 李晓华,邵秋香,常文丽,等.中药灌肠方直肠滴入联合葛根芩连汤加味内服治疗溃疡性直肠炎的临床疗效[J].安徽医药,2026,30(1):193-197. |
| 中药灌肠方直肠滴入联合葛根芩连汤加味内服治疗溃疡性直肠炎的临床疗效 |
| Clinical efficacy of rectal infusion of traditional Chinese medicine enema formula combined with oral administration of modified Gegen Qinlian decoction in treating ulcerative proctitis |
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| DOI：10.3969/j.issn.1009-6469.2026.01.039 |
| 中文关键词: 溃疡性直肠炎 投药，直肠 中药灌肠方 白头翁 葛根芩连汤加味 葛根 炎症因子 疗效 |
| 英文关键词: Ulcerative proctitis Administration, rectal Traditional Chinese medicine enema formula Radix pulsatillae Modi-fied Gegen Qinlian decoction Radix puerariae Inflammatory factors Curative effect |
| 基金项目:河北省中医药管理局项目( 2021320) |
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| 中文摘要: |
| 目的探讨中药灌肠方直肠滴入联合葛根芩连汤加味内服治疗溃疡性直肠炎的临床疗效。方法选取 2020年 6月至 2021年 12月河北省沧州中西医结合医院 90例溃疡性直肠炎病人，按随机数字表法将其均分为两组，各 45例。对照组病人给予美沙拉嗪栓纳肛治疗，治疗组病人给予中药灌肠方直肠滴入联合葛根芩连汤加味内服治疗，治疗 3周后，比较两组临床疗效。结果治疗组较对照组总有效率升高［34例( 75.56%)比 42例( 93.33%)P<0.05］；治疗后，治疗组较对照组血清白细胞介素 -6［( 1.94±0.56)ng/L比( 2.61±0.82)ng/L］、 C反应蛋白［( 8.62±2.25)mg/L比，(16.34±5.04)mg/L］及肿瘤坏死因子 α［( 35.06±9.63)ng/L比( 41.81±10.89)ng/L］水平均降低( P<0.05)；治疗后，治疗组病人中文版炎症性肠病问卷( IBDQ)中 4个维度评分均高于对照组( P<0.05)。结论中药灌肠方直肠滴入联合葛根芩连汤加味内服治疗溃疡性直肠炎疗效显著，可明显缓解症状，减轻炎症反应，提高生活质量。 |
| 英文摘要: |
| Objective To explore the clinical efficacy of rectal infusion of traditional Chinese medicine enema formula combinedwith oral administration of modified Gegen Qinlian decoction in treating ulcerative proctitis.Methods Ninety patients with ulcer-ative proctitis in Cangzhou Hospital of Integrated TCM-WM·Hebei from June 2020 to December 2021 were selected and randomlydivided into two groups of 45 cases each by the random number table method. The control group received anal administration of me-salazine suppositories, while the treatment group received rectal infusion of traditional Chinese medicine enema formula combinedwith oral administration of modified Gegen Qinlian decoction. After 3 weeks of treatment, the clinical efficacy of the two groups was compared. Results The total effective rate of the treatment group was higher than that in the control group [34(75.56%) vs. 42 (93.33%),P<0.05]; After treatment, serum interleukin-6 [(1.94 ± 0.56) ng/L vs. (2.61 ± 0.82) ng/L], C-reactive protein [(8.62 ± 2.25) mg/L vs. (16.34 ± 5.04) mg/L] and tumor necrosis factor-α [(35.06 ± 9.63) ng/L vs. (41.81 ± 10.89) ng/L] levels in the treatment group were all lower than those in the control group (P<0.05); after treatment, the scores of the four dimensions in the Chinese version ofthe inflammatory bowel disease questionnaire (IBDQ) for the patients in the treatment group were all higher than those of the controlgroup (P<0.05).Conclusion The combination of rectal infusion of traditional Chinese medicine enema formula and oral administra-tion of modified Gegen Qinlian decoction has an obvious therapeutic effect on ulcerative proctitis, which can obviously alleviate symp-toms, reduce inflammatory reactions, and improve quality of life. |
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