| 钟日梅,陈煜森,王小静,等.髓鞘少突胶质细胞糖蛋白抗体相关疾病合并抗 -N-甲基 -D-天冬氨酸受体脑炎的临床研究进展[J].安徽医药,2026,30(2):213-218. |
| 髓鞘少突胶质细胞糖蛋白抗体相关疾病合并抗 -N-甲基 -D-天冬氨酸受体脑炎的临床研究进展 |
| Progress in clinical studies of MOGAD overlap with anti-NMDAR encephalitis |
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| DOI：10.3969/j.issn.1009-6469.2026.02.001 |
| 中文关键词: 神经系统自身免疫疾病 N-甲基 -D-天冬氨酸受体脑炎 髓鞘少突胶质细胞糖蛋白抗体相关疾病 抗体 重叠综合征 综述 |
| 英文关键词: Autoimmune diseases of the nervous system N-methyl-D-aspartate receptor encephalitis Myelinating oligodendrocyte glycoprotein antibody-associated disease Antibody Overlap syndrome Review |
| 基金项目:国家自然科学基金项目( 32300628) |
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| 摘要点击次数: 630 |
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| 中文摘要: |
| 抗 N-甲基 -D-天冬氨酸受体( NMDAR)脑炎是一种自身免疫性抗体介导的脑部疾病，可伴有脱髓鞘疾病，包括多发性硬化症( MS)、视神经脊髓炎谱系疾病( NMOSD)和髓鞘少突胶质细胞糖蛋白抗体相关疾病( MOGAD)。其中以 MOGAD合并抗 NMDAR脑炎备受学者关注，因为 NMDAR-ab与 MOG-ab的共存较其他自身免疫性抗体在临床中更常见。这种 MOGAD与抗 NMDAR脑炎重叠出现的情况，目前被称为 MOG抗体病及抗 NMDAR脑炎重叠综合征( MNOS)。然而，由于 MNOS在临床上的罕见性，目前其潜在发病机制、临床表现、影像学特征和诊治尚未完全明确。现针对 MOGAD合并抗 NMDAR脑炎重叠综合征作一综述，通过总结现有文献，阐述 MNOS的临床特征，探讨其免疫反应的可能机制。以期为临床工作者对该病的诊断及治疗提供参考。 |
| 英文摘要: |
| Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune antibody-mediated brain disease that can be associated with demyelinating disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and my-elinating oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Among them, MOGAD combined with anti-NMDAR en-cephalitis has attracted much attention from scholars because the coexistence of NMDAR-ab and MOG-ab is more common than other autoimmune antibodies in the clinic. This overlap between MOGAD and anti-NMDAR encephalitis is currently referred to as MOG anti-body disease and anti-NMDAR encephalitis overlap syndrome (MNOS). However, due to the clinical rarity of MNOS, the underlyingpathogenesis, clinical manifestations, imaging features, and diagnosis and treatment have not yet been fully clarified. This article pro-vides a review of MOGAD combined with anti-NMDAR encephalitis overlap syndrome. By summarizing the existing literature, we de-scribe the clinical features of MNOS and explore the possible mechanisms of its immune response. We hope to provide reference forclinical workers in the diagnosis and treatment of this disease. |
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