| 陆仁科,罗班,胡维琨.肠道菌群与甲状腺相关眼病关系研究进展[J].安徽医药,2026,30(2):218-222. |
| 肠道菌群与甲状腺相关眼病关系研究进展 |
| Research progress on the relationship between gut microbiota and thyroid-associated ophthalmopathy |
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| DOI：10.3969/j.issn.1009-6469.2026.02.002 |
| 中文关键词: 甲状腺眼病 肠道菌群 自身免疫性疾病 眼眶病 辅助 T细胞 17细胞 调节性 T细胞 肠 -眼轴 动物模型 |
| 英文关键词: Thyroid eye disease Intestinal flora Autoimmune disease Orbital disease Helper T cell 17 cells Regulatory T cells Gut-eye axis Animal model |
| 基金项目:湖北省卫生健康委员会科研项目( WJ2021M211) |
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| 中文摘要: |
| 甲状腺相关眼病( TAO)是一种器官特异性的自身免疫性疾病，是成年人最常见的眼眶病。它可以影响病人的面部外貌和视觉功能，严重降低其生活质量。然而，其发病机制复杂，目前缺乏有效的治疗方法。过去，小鼠模型的建立和病人的临床研究表明，肠道微生物群失调可能参与了 TAO的发病过程，并发挥了关键性的作用。在 TAO小鼠模型中，万古霉素的使用减轻了疾病的严重程度，而粪便微生物移植加重了疾病的严重程度。在 TAO中影响免疫失调的主要机制主要源于辅助性 T细胞 17(Th17)和调节性 T细胞( Tregs)之间的失衡以及抗原模拟。未来的研究将揭示连接肠 -眼轴的分子代谢途径，从而有助于开发新的治疗方法。 |
| 英文摘要: |
| Thyroid-associated ophthalmopathy (TAO) is an organ-specific autoimmune disease, representing the most common orbitaldisease in adults. It can affect the patient's facial appearance and visual function, seriously reducing their quality of life. However, thepathogenesis is complex, and effective treatment methods are currently lacking. In the past, the establishment of mice models and clini-cal studies in patients, suggesting that dysregulation of gut microbiota may be implicated in the pathogenesis of TAO, playing a pivotalrole. In the TAO mouse model, the administration of vancomycin alleviated the severity of the disease, while fecal microbiota transplan-tation exacerbated the severity of the disease. The principal mechanism influencing immune dysregulation in TAO primarily stems fromthe imbalance between helper T cell 17 cells (Th17) and regulatory T cells (Tregs), along with antigen simulation. Future investigationsare poised to unveil the molecular metabolic pathways linking the gut-eye axis, thereby contributing to the development of novel thera-peutic approaches. |
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