| 谷佳斐,陆晓媛,孙洁芸,等.基质金属蛋白酶 7、基质金属蛋白酶组织抑制物 1和弹性蛋白在绝经生殖泌尿综合征病人血清中的表达及临床意义[J].安徽医药,2026,30(2):305-309. |
| 基质金属蛋白酶 7、基质金属蛋白酶组织抑制物 1和弹性蛋白在绝经生殖泌尿综合征病人血清中的表达及临床意义 |
| Expression and clinical significance of MMP-7, TIMP-1 and Elastin in the serum of patients with genitourinary syndrome of menopause |
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| DOI：10.3969/j.issn.1009-6469.2026.02.018 |
| 中文关键词: 绝经生殖泌尿综合征 基质金属蛋白酶 7 基质金属蛋白酶组织抑制物 1 弹性蛋白 组血， |
| 英文关键词: Genitourinary syndrome of menopause Matrix metalloproteinase-7 Tissue inhibitor of metalloprotein-1 Elastin |
| 基金项目:徐州市科技重点研发计划(社会发展)项目( KC22246) |
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| 中文摘要: |
| 目的探究基质金属蛋白酶 7(MMP-7)、基质金属蛋白酶组织抑制物 1(TIMP-1)和弹性蛋白(Elastin)在绝经生殖泌尿综合征(GSM)病人血清中的表达水平与临床意义。方法选取 2023年 2―7月徐州医科大学附属医院更年期门诊就诊的绝经后病人 120例，根据有无 GSM症状及体征分为 GSM组和非 GSM组，各 60例。采用随机数据表法选取 60例体检健康的 30~40岁未绝经女性为健康对照组。比较三组病人血清中 MMP-7、TIMP-1和 Elastin的表达情况和血清中雌二醇( E2)和卵泡生成素(FSH)水平；比较 GSM组和非 GSM组病人一般临床资料的差异，并分析 GSM组病人血清中 MMP-7、TIMP-1和 Elastin的关系。结果 GSM组和非 GSM组病人的年龄、绝经时间、分娩次数、初潮年龄比较均差异无统计学意义( P>0.05)； GSM组和非 GSM组病人改良 Kupperman评分［(19.00±3.79)分比( 12.80±2.45)分］、阴道健康指数评分( VHIS)［(10.97±1.62)分比( 16.32±1.68)分］、国际失禁问卷调查表评分( ICIQ-SF)［( 2.42±2.65)分比( 1.10±2.02)分］、阴道 pH(5.55±0.52比 4.93±0.41)均差异有统计学意义(P<0.05)。三组血清 MMP-7、TIMP-1、Elastin、雌二醇和 FSH水平经 Kruskal-Wallis H检验，差异有统计学意义( P<0.05)进一步采用 Nemenyi法两两比较， GSM组 MMP-7值高于非 GSM组和健康对照组( P<0.05)，非 GSM组 MMP-7值高于健康对照组，(P<0.05)。 GSM组 TIMP-1值和 Elastin值均低于非 GSM组、健康对照组( P<0.05)，非 GSM组 TIMP-1值和 Elastin值均低于健康对照组( P<0.05)； GSM组和非 GSM组雌二醇和 FSH水平比较差异无统计学意义(P>0.05)健康对照组雌二醇水平均高于 GSM组、非 GSM组(P<0.05)；健康对照组 FSH水平均低于 GSM组和非 GSM组( P<0.05)； GSM清 MMP-7值与 TIMP-1值、 Elastin值均呈负相关(P<0.01)。结论 MMP-7表达水平升高、 TIMP-1和 Elastin表达水平降低与绝经生殖泌尿综合征发病有一定关系。 |
| 英文摘要: |
| Objective To investigate the expression levels and clinical significance of matrix metalloproteinase-7 (MMP-7), tissue in-hibitor of metalloprotein-1 (TIMP-1) and elastin in the serum of patients with genitourinary syndrome of menopause (GSM).Methods One hundred and twenty postmenopausal patients attending the menopause outpatient clinic of the Hospital of the Affiliated Hospital ofXuzhou Medical University from February 2023 to July 2023 were selected and categorized into the GSM group and the non-GSM group according to the presence or absence of GSM symptoms and signs, with 60 cases in each group. Sixty cases of non-menopausal women aged 30-40 years old who had a health checkup were randomly selected as the healthy control group. The expression of MMP-7,TIMP-1 and elastin in serum and the levels of estradiol (E2) and follicle-stimulating hormone (FSH) in serum of the three groups were compared.The differences in general clinical data between patients in the GSM group and the non-GSM group were compared, and the relation-ship between MMP-7,TIMP-1 and elastin in serum of patients in the GSM group were analyzed.Results There was no statistically sig-nificant difference in age, menopause time, number of deliveries, and age at menarche when comparing the patients in the GSM groupand non-GSM group (P>0.05); Differences in modified Kupperman score [(19.00±3.79)points vs. (12.80±2.45)points], vaginal health in-dex score(VHIS) [(10.97±1.62)points vs. (16.32±1.68)points], International Consultation Incontinence Questionnaire Short Form (ICIQ-SF) [(2.42±2.65)points vs. (1.10±2.02)points], and vaginal pH (5.55±0.52 vs. 4.93±0.41) were statistically significant in both groups (P<0.05). Serum MMP-7, TIMP-1, elastin, E2 and FSH levels in the three groups showed statistically significant differences (P<0.05) by the Kruskal-Wallis H test, Nemenyi method was further showed that MMP-7 value was higher in the GSM group than in the non-GSM group and the healthy control group(P<0.05), and MMP-7 value was higher in the non-GSM group than in the healthy control group(P< 0.05); TIMP-1 and elastin values were lower in the GSM group than in the non-GSM group and the healthy control group (P<0.05), and TIMP-1 and elastin values were lower in the non-GSM group than in the healthy control group (P<0.05); There was no statistically sig-nificant difference between the E2 and FSH levels in the GSM and non-GSM groups (P>0.05), while the E2 levels in the healthy control group were higher than those in the GSM and non-GSM groups (P<0.05); the FSH levels in the healthy control group were higher than those in the GSM and non-GSM groups (P<0.05); and serum MMP-7 values in the GSM group were negatively correlated with both TIMP-1 values and elastin.Conclusion Elevated levels of MMP-7 expression and decreased levels of TIMP-1 and elastin expression are associated with the development of menopausal genitourinary syndrome. |
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