| 陈亚男,孙珂,王玉.超声脐血流参数对子痫前期孕妇胎儿生长受限的预测价值[J].安徽医药,2026,30(2):330-333. |
| 超声脐血流参数对子痫前期孕妇胎儿生长受限的预测价值 |
| Value of ultrasonic cord blood flow parameters in predicting FGR in patients with preeclampsia |
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| DOI：10.3969/j.issn.1009-6469.2026.02.023 |
| 中文关键词: 子痫前期 胎儿生长受限 脐动脉 阻力指数 搏动指数 |
| 英文关键词: Preeclampsia Fetal growth restriction Umbilical artery Resistance index Pulsation index |
| 基金项目:安徽省高等学校科学研究项目( 2022AH051436) |
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| 中文摘要: |
| 目的探讨超声脐血流参数对子痫前期( PE)孕妇胎儿生长受限( FGR)的预测价值，并分析其 FGR发生的影响因素。方法纳入 2020年 12月至 2024年 3月淮北市人民医院收治的 PE孕妇 65例，根据有无 FGR分成 FGR组、非 FGR组。比较两组临床资料及超声脐血流参数，脐血流参数包括脐动脉阻力指数( RI)、搏动指数( PI)收缩期最大血流速度与舒张末期血流速度比值( S/D)。通过受试者操作特征曲线( ROC曲线)分析超声脐血流参数评估 PE孕妇、FGR发生的曲线下面积( AUC)。利用多因素 logistic回归模型分析 PE孕妇 FGR发生的影响因素。结果 65例 PE孕妇中， FGR发生率为 56.92%(37/65)。 FGR组羊水过少、尿蛋白定量 ≥2.0 g/24 h的比例较非 FGR组更高( P<0.05)。 FGR组的脐动脉 RI(0.71±0.09比 0.58±0.07)、 PI(1.15±0.13比 0.82±0.17)、 S/D(3.04±0.22比 2.59±0.28)较非 FGR组更高( P<0.05)。脐动脉 RI、PI、S/D预测 PE孕妇 FGR发生的 AUC(灵敏度、特异度)分别为 0.76(86.49%、57.14%)、 0.82(67.57%、85.71%)、 0.83(83.78%、71.43%)。脐动脉 RI、PI联合 S/D预测 PE孕妇 FGR发生的 AUC(灵敏度、特异度)为 0.93(89.19%、89.29%)。 logistic回归分析显示，羊水过少、尿蛋白定量 ≥2.0 g/24 h及脐动脉 RI、PI、S/D增高是 PE孕妇发生 FGR的独立影响因素( P<0.05)。结论 PE孕妇 FGR发生率较高，且 FGR发生者脐动脉 RI、 PI、S/D增高，上述参数可以预测 PE孕妇 FGR的发生，且羊水过少、尿蛋白定量 ≥2.0 g/24 h及脐动脉 RI、PI、S/D增高与 FGR发生密切相关。 |
| 英文摘要: |
| Objective To investigate the value of ultrasonic cord blood flow parameters in predicting fetal growth restriction (FGR) inpregnant women with preeclampsia (PE), and analyze the influencing factors of FGR.Methods Sixty-five pregnant women with PE ad-mitted to the People's hospital of Huaibei from December 2020 to March 2024 were included and divided into FGR group and non-FGR group according to whether or not they had FGR. The clinical data and ultrasonic cord blood flow parameters of the two groupswere compared, including umbilical artery resistance index (RI), pulsation index (PI), and the ratio of maximum systolic blood flow ve-locity to end-diastolic blood flow velocity (S/D).The area under the curve (AUC) of FGR in PE pregnant women was evaluated by receiv-er operating characteristic (ROC) curve analysis of ultrasonic cord blood flow parameters. Multivariate logistic regression model was used to analyze the influencing factors of FGR in PE pregnant women.Results Among 65 PE pregnant women, the incidence of FGRwas 56.92% (37/65). The proportion of oligohydramnios and urinary protein ≥2.0 g/24 h in FGR group was higher than that in non-FGR group (P<0.05). The umbilical artery RI,PI and S/D in FGR group were higher than those in non-FGR group (P<0.05). The AUC (sensi-tivity and specificity) of umbilical artery RI (0.71±0.09 vs. 0.58±0.07), PI (1.15±0.13 vs. 0.82±0.17) and S/D (3.04±0.22 vs. 2.59±0.28)for predicting FGR in PE pregnant women were 0.76(86.49%, 57.14%), 0.82(67.57%, 85.71%) and 0.83(83.78%, 71.43%), respective-ly. The AUC (sensitivity and specificity) of umbilical artery RI and PI combined with S/D to predict FGR in PE pregnant women was0.93 (89.19%,89.29%). Logistic regression analysis showed that oligohydramnios, urinary protein quantity ≥2.0 g/24 h and umbilical ar-tery RI, PI and S/D increase were independent influencing factors for FGR in PE pregnant women (P<0.05).Conclusions The inci-dence of FGR is higher in PE pregnant women, and the incidence of FGR increases in umbilical artery RI, PI, and S/D. The above pa-rameters can predict the occurrence of FGR in PE pregnant women, and the hypomniotic fluid, urinary protein quantity≥2.0 g/24 h, andthe increase in umbilical artery RI,PI,and S/D are closely related to the occurrence of FGR. |
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