| 朱廷廷,张倩,向玲.血府逐瘀汤联合地屈孕酮治疗血瘀型经间期出血 59例疗效观察[J].安徽医药,2026,30(2):387-392. |
| 血府逐瘀汤联合地屈孕酮治疗血瘀型经间期出血 59例疗效观察 |
| Observation of curative effect of Xuefuzhuyu decoction combined with didrogesterone in treating intermenstrual bleeding of blood stasis type |
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| DOI：10.3969/j.issn.1009-6469.2026.02.033 |
| 中文关键词: 经间期出血 血府逐瘀汤 地屈孕酮 雌激素 孕激素 促卵泡激素 |
| 英文关键词: Intermenstrual bleeding Xuefuzhuyu decoction ing hormone |
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| 中文摘要: |
| 目的观察血府逐瘀汤联合地屈孕酮治疗血瘀型经间期出血的疗效。方法选取 2022年 6月至 2024年 1月遂宁市中医院就诊的 118例经间期出血病人，采用随机数字表法分为两组，每组 59例。对照组口服地屈孕酮片，每次服用 10 mg，每天 1次。观察组在对照组基础上加用血府逐瘀汤，每次 200 mL，日服 2次。两组病人均在月经周期第 5天时开始服用各自药物，连续使用 21 d后停止药物，然后在下一个月经周期的第 5天重新开始服药，连续治疗 3个月。比较两组临床疗效、中医证候积分、生活质量、基础体温、性激素、子宫内膜厚度等指标。结果观察组表现出明显较高的总有效率，与对照组相比差异有统计学意义( 93.22%比 79.66%，P<0.05)，治疗后，观察组的中医证候积分显著低于对照组的数值( P<0.05)。此外，治疗后两组的中医证候积分都比治疗前有所下降( P<0.05)此外，治疗后两组的出血量及出血时间评分都比治疗前有所下降( P<0.05)，治疗后，观察组的生活质量评分高于对照组( P<0.0，5)。此外，治疗后两组的生活质量评分都比治疗前有所上升( P<0.05)观察组与对照组的基础体温类型相比，差异有统计学意义( P<0.05)，然而，在接受治疗后，观察组的雌二醇水平明显高于对照组(，P<0.05)，两组 P及 FSH水平差异无统计学意义( P>0.05)。此外，治疗后两组的雌二醇、 P水平都比治疗前有所上升， FSH水平比治疗前有所下降( P<0.05)。治疗后，两组的子宫内膜厚度差异无统计学意义( P>0.05)。此外，治疗后两组的子宫内膜厚度分别与治疗前相比差异无统计学意义(P>0.05)，观察组不良反应发生率显著低于对照组( P<0.05)。结论口服地屈孕酮片加用血府逐瘀汤能够显著提高经间期出血病人的临床疗效，改善中医证候，提高生活质量，调节体温代谢和性激素水平，具有很好的临床应用价值，值得推广应用。 |
| 英文摘要: |
| Objective To observe the curative effect of Xuefuzhuyu decoction combined with didrogesterone in treating intermenstru-al bleeding of blood stasis type. Methods A total of 118 patients with intermenstrual bleeding in Suining Traditional Chinese Medi-cine Hospital from June 2022 to January 2024 were selected and divided into two groups by random number table method, with 59 cas-es in each group .The control group was orally administered with 10 mg of progesterone tablets once a day. The observation group re-ceived 200 mL of Xuefuzhuyu Tang in addition to the control group, taken twice a day. Patients in both groups began their medicationson the fifth day of their menstrual cycles and discontinued use after 21 days of continuous treatment, and then resumed taking the medi-cation on the 5th day of the next menstrual cycle for 3 months of continuous treatment. The clinical efficacy, TCM syndrome score, qual-ity of life, basal body temperature, sex hormones, endometrial thickness and other indicators between two groups were compared. Re. sults The observation group showed a significantly higher total effective rate compared to the control group (93.22% vs. 79.66%,P< 0.05). Following the treatment, the syndrome score for Traditional Chinese Medicine in the observation group was markedly lower com-pared to the control group (P<0.05). In addition, the TCM syndrome scores of both groups decreased after treatment compared to before treatment (P<0.05). Following treatment, the observation group's bleeding volume and bleeding time scores were significantly reducedcompared to the control group (P<0.05). Following the intervention, the life quality score in the observation group surpassed that of the control group (P<0.05).In addition, the quality of life scores of both groups increased after treatment compared to before treatment (P< 0.05). There was a significant difference in basal body temperature types between the observation group and the control group (P<0.05).Nonetheless, following the treatment, the E2 concentration in the observation group was considerably elevated compared to that of thecontrol group (P<0.05). In addition, after treatment, the levels of E2 and P in both groups increased compared to before treatment, whilethe level of FSH decreased compared to before treatment(P<0.05). Following treatment, the endometrial thickness did not show a statis-tically significant difference between the two groups (P>0.05). Moreover, there were no noteworthy changes in endometrial thickness ob-served between the two groups prior to and following treatment (P>0.05). Additionally, the occurrence of adverse reactions in the obser-vation group was considerably less than that in the control group (P<0.05). Conclusion Oral dedrogesterone tablets combined with Xuefuzhuyu decoction can significantly improve the clinical efficacy of patients with intermenstrual bleeding, improve the syndrome oftraditional Chinese medicine, improve the quality of life, regulate body temperature metabolism and sex hormone levels, and have good clinical application value, worthy of promotion and application. |
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