| 刘祥彪,程晓昱,胡业彬,等.复方真武冲剂治疗阳虚水泛型心力衰竭临床疗效及对心室重构、炎症因子水平的影响[J].安徽医药,2026,30(2):398-403. |
| 复方真武冲剂治疗阳虚水泛型心力衰竭临床疗效及对心室重构、炎症因子水平的影响 |
| Clinical effect of compound Zhenwu granule in the treatment of Yang deficiency and water inundation type heart failure and its effect on ventricular remodeling |
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| DOI：10.3969/j.issn.1009-6469.2026.02.035 |
| 中文关键词: 心力衰竭 复方真武冲剂 阳虚水泛型 心室重构 |
| 英文关键词: Heart failure Compound Zhenwu granule Yang deficiency and water inundation type Ventricular remodeling |
| 基金项目:安徽省中医药学术流派传承工作室建设项目(皖中医药发展秘﹝ 2021〕30号)；胡业彬省名中医工作室项目(中医药发展秘﹝ 2021〕8号) |
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| 中文摘要: |
| 目的观察复方真武冲剂治疗阳虚水泛型心力衰竭的临床疗效，并探索其对心功能、心室重构及炎症因子水平的影响。方法选择 2023年 5月至 2024年 3月安徽中医药大学第一附属医院老年病中心心血管内科收治心力衰竭(阳虚水泛型)病人 60例。采用随机数字表法分组，对照组采用正规西药治疗，观察组在对照组基础上加服复方真武冲剂，疗程均为 4周。统计两组治疗前后临床疗效，评估病人 6 min步行试验的距离( 6-minute walk test，6MWT)检测并比较两组病人的心功能［氨基末端脑利钠肽前体( NT-proBNP)、左心室射血分数( LVEF)］、心室重构［左心室舒张期，末内径( LVEDD)、左心室收缩期末内径(LVESD)］、炎症因子［ C反应蛋白(CRP)、降钙素原( PCT)白细胞介素 -6(IL-6)和血清淀粉样蛋白 A(SAA)］等指标。结果经治疗后观察组心功能改善总有效率为 93.3%，明显高于对照、组总有效率 76.7%(χ2=6.05，P<0.05)。两组治疗后，观察组 6MWT距离增加多于对照组［( 488.97±52.65)m比( 455.43±43.08)m，P<0.05］观察组 NT-proBNP水平较对照组下降更明显［( 106.19±26.74)ng/L比( 134.38±28.10)ng/L，P<0.05］，观察组 LVEF提高程度对照组［( 54.10±4.29)%比( 47.50±3.81)%，P<0.05］，观察组 LVEDD、LVESD较对照组下降更明显( P<0.05)，观察组 CRP、PCT、IL-6和 SAA水平均较对照组下降更明显( P<0.05)。结论复方真武冲剂联合常规西较单纯西药更好地改善阳虚水泛型心力衰竭病人心脏功能，逆转心室重构，减轻炎症反应，其机优于， |
| 英文摘要: |
| Objective To observe the clinical efficacy of compound Zhenwu granule in the treatment of Yang deficiency and water in-undation type of heart failure, and to explore the possible mechanisms of its effects on cardiac function, ventricular remodeling and in-flammatory factor levels.Methods From May 2023 to March 2024, 60 patients with heart failure ( Yang deficiency and water inunda-tion type) were selected from the Department of Cardiovascular Medicine of the Geriatrics Center of the First Affiliated Hospital of An-hui University of Traditional Chinese Medicine. Grouped by random number table method, the control group was treated with regularwestern medicine, and the observation group was treated with compound Zhenwu granule on the basis of the control group. The courseof treatment was 4 weeks. The clinical efficacy of the two groups before and after treatment was counted, and the 6MWT was evaluated.The cardiac function (NT-proBNP, LVEF, LVEDD ,LVESD), inflammatory factors (CRP,PCT, IL-6 and SAA) were detected and com-pared between the two groups.Results After treatment, the total effective rate for cardiac function improvement was significantly high-er in the observation group (93.3%) than in the control group (76.7%) (χ2=6.05, P<0.05). Compared with the control group, the observa-tion group demonstrated a greater increase in the 6MWT distance [(488.97±52.65)m vs. (455.43±43.08)m, P<0.05], a more pronounced reduction in NT-proBNP levels [(106.19±26.74)ng/L vs. (134.38±28.10)ng/L, P<0.05], and better improvement in LVEF [(54.10± 4.29)% vs. (47.50±3.81)%, P<0.05]. Additionally, LVEDD and LVESD were significantly more reduced in the observation group than in the control group (P<0.05). Moreover, the levels of inflammatory markers, including CRP,PCT, IL-6, SAA, decreased more markedly in the observation group (P<0.05).Conclusions Compound Zhenwu granule combined with conventional western medicine is betterthan western medicine alone in improving cardiac function, reversing ventricular remodeling and reducing inflammatory response in pa-tients with Yang deficiency and water inundation type heart failure. The mechanism may be related to its better inhibition of myocardialcell inflammatory response. |
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