| 唐蓉,潘海英,王庆,等.系统性红斑狼疮对女性生育能力及母儿并发症影响的研究进展[J].安徽医药,2026,30(3):425-429. |
| 系统性红斑狼疮对女性生育能力及母儿并发症影响的研究进展 |
| Research advances on the impact of systemic lupus erythematosus on female fertility and maternal-fetal complications |
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| DOI：10.3969/j.issn.1009-6469.2026.03.001 |
| 中文关键词: 红斑狼疮，系统性 妊娠 母儿并发症 子痫前期 不孕 早产 |
| 英文关键词: Lupus erythematosus, systemic Pregnancy Maternal-fetal complications Preeclampsia Infertility Preterm birth |
| 基金项目:国家重点研发计划项目( 2017YFC0113905) |
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| 摘要点击次数: 594 |
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| 中文摘要: |
| 系统性红斑狼疮(SLE)是一种免疫系统被异常激活，攻击自身组织导致的慢性弥漫性结缔组织疾病。 SLE可损害血管、大脑、肺、皮肤、关节等正常器官及组织，不仅降低女性病人生育能力，诱发不孕，还可导致母儿妊娠期间出现子痫前期、甲状腺功能减退症、神经精神性狼疮、感染、胚胎停育、复发性流产、早产、胎儿生长受限、先天性心脏传导阻滞等并发症，严重威胁 SLE病人母儿健康。该综述旨在深入分析 SLE对女性病人生育能力及母儿并发症的影响，以期为 SLE的生育指导及围生期管理提供参考。 |
| 英文摘要: |
| Systemic lupus erythematosus (SLE) is a chronic diffuse connective tissue disease resulting from aberrant immune systemactivation that attacks the body's own tissues. SLE can damage various organs and tissues such as blood vessels, the brain, lungs, skin,and joints. It not only reduces fertility in female patients, potentially leading to infertility, but can also cause various maternal and fetalcomplications during pregnancy. It impairs female fertility and may lead to infertility. Moreover, SLE is associated with an increasedrisk of numerous pregnancy complications, such as preeclampsia, hypothyroidism, neuropsychiatric lupus, infection, embryonic demise,recurrent miscarriage, preterm delivery, fetal growth restriction, and congenital heart block, which pose a serious threat to the health ofboth the mother and the fetus in SLE patients. This review aims to provide an in-depth analysis of the impact of SLE on female fertility and maternal-fetal complications, to offer insights for fertility counseling and perinatal management in SLE. |
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