| 齐乐,孙丹.脑炎后癫痫的研究进展[J].安徽医药,2026,30(3):446-450. |
| 脑炎后癫痫的研究进展 |
| Research progress in postencephalitic epilepsy |
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| DOI：10.3969/j.issn.1009-6469.2026.03.005 |
| 中文关键词: 脑炎 癫痫 单纯疱疹病毒 自身抗体 治疗 |
| 英文关键词: Encephalitis Epilepsy Herpes simplex virus Autoantibodies Treatment |
| 基金项目:湖北省科技计划立项项目( 2022DCC020) |
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| 摘要点击次数: 318 |
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| 中文摘要: |
| 急性脑炎是脑实质受病原体侵犯导致的大脑炎症性疾病，其中以病毒性脑炎最为常见，而近年来自身免疫性脑炎也被越来越多的人认识到。急性脑炎临床上通常表现为发热、癫痫发作、运动障碍、局灶性神经功能障碍以及意识水平的改变，更有部分脑炎病人在恢复期遗留身体、神经及心理等方面缺陷，需要长期治疗。急性脑炎遗留的并发症之一就是脑炎后癫痫，更有约 50%的病人进展为难治性癫痫，因此脑炎后癫痫也是 3~10岁儿童癫痫常见的一类。目前研究发现某些因素影响急性脑炎进展为癫痫，而临床医师可以通过早期判断并及时干预这些影响因素来减少其进展为癫痫的概率。因此该文就脑炎后癫痫的流行病学、发病机制、治疗措施及预后等方面进行综述，以期加强对脑炎后癫痫的认识。 |
| 英文摘要: |
| Acute encephalitis is an inflammatory disease of the brain parenchyma caused by pathogenic invasion, with viral encephali.tis being the most common. In recent years, autoimmune causes have also been increasingly recognized. Clinically, acute encephalitistypically presents with fever, seizures, movement disorders, focal neurological deficits, and altered consciousness. Furthermore, somepatients experience residual physical, neurological, and psychological deficits during the recovery phase, necessitating long-term man. agement. One of the complications following acute encephalitis is postencephalitic epilepsy, and approximately 50% of affected pa.tients progress to refractory epilepsy. Consequently, postencephalitic epilepsy is also a prevalent type of epilepsy in children aged 3– 10 years. Current research has identified specific factors influencing the progression from acute encephalitis to epilepsy. Clinicians canreduce this risk by early identification and timely intervention targeting these factors. Therefore, this article reviews the epidemiology,pathogenesis, treatment, and prognosis of postencephalitic epilepsy to enhance understanding of this condition. |
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