| 王庆,肖跃海,孙发.生物标志物对前列腺特异性抗原灰区前列腺癌早期诊断价值的研究进展[J].安徽医药,2026,30(3):461-465. |
| 生物标志物对前列腺特异性抗原灰区前列腺癌早期诊断价值的研究进展 |
| Advancements in biomarkers for the early diagnosis of prostate cancer within the prostate specific antigen gray zone |
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| DOI：10.3969/j.issn.1009-6469.2026.03.008 |
| 中文关键词: 前列腺肿瘤 诊断 前列腺特异性抗原 前列腺特异性抗原灰区 生物标志物 |
| 英文关键词: Prostatic neoplasms Diagnosis Prostate specific antigen Prostate specific antigen gray area Biomarker |
| 基金项目:贵州省科技计划项目(黔科合基础［2020］1Y309)；贵州医科大学附属医院博士基金项目( I-2017-13) |
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| 中文摘要: |
| 前列腺癌是老年男性常见的恶性肿瘤之一，发病率逐渐增加。早期诊断和治疗对延长生存期、降低病死率以及提高老年病人的生活质量意义重大。目前前列腺癌的诊断主要依靠血清前列腺特异性抗原( PSA)筛查及前列腺穿刺活检确诊。近年来，有许多新型诊断方法对早期前列腺癌的诊断有重要参考价值，尤其是对 PSA灰区前列腺癌的诊断意义重大，可避免不必要的前列腺穿刺活检和过度治疗，但其有效性及实用性还需大量的研究进一步验证。该文就生物标志物对 PSA灰区前列腺癌的早期诊断价值作一综述，以期为临床研究提供参考依据。 |
| 英文摘要: |
| Prostate cancer is one of the most common malignancies in elderly men, with a progressively increasing incidence. Early di.agnosis and treatment are crucial for prolonging survival, reducing mortality, and enhancing the quality of life for aged patients. Current.ly, the diagnosis of prostate cancer primarily relies on serum prostate-specific antigen (PSA) screening and is confirmed by prostate nee.dle biopsy. In recent years, numerous novel diagnostic approaches have emerged, offering significant promise for the early detection ofprostate cancer. These advancements are particularly valuable for diagnosing patients within the PSA gray zone, potentially avoiding un.necessary biopsies and overtreatment. Nevertheless, the efficacy and clinical utility of these methods require further validation throughextensive research. This article reviews the value of biomarkers in the early diagnosis of prostate cancer within the PSA gray zone, aim.ing to provide a reference for clinical research. |
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