| 霍俊燕,闫虹佑,许翠萍.抗生素在炎症性肠病发生及治疗中作用的研究进展[J].安徽医药,2026,30(3):466-475. |
| 抗生素在炎症性肠病发生及治疗中作用的研究进展 |
| Research progress on the role of antibiotics in the occurrence and treatment of inflammatory bowel disease |
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| DOI：10.3969/j.issn.1009-6469.2026.03.009 |
| 中文关键词: 炎症性肠病 肠道菌群失调 抗生素 溃疡性结肠炎 克罗恩病 治疗 |
| 英文关键词: Inflammatory bowel disease Intestinal flora dysregulation Antibiotic Ulcerative colitis Crohn's disease Therapy |
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| 摘要点击次数: 319 |
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| 中文摘要: |
| 炎症性肠病( IBD)是一种以胃肠道慢性复发性炎症为特征的疾病。 IBD的发生与肠道菌群失调相关。一方面，抗生素导致肠道菌群失调，增加 IBD患病风险；另一方面，抗生素可能通过减少肠道来源毒素等对 IBD起治疗作用。该文综述了研究生命不同阶段抗生素暴露与 IBD发病关系的人群研究及动物实验，同时评估了抗生素治疗 IBD的临床研究。 |
| 英文摘要: |
| Inflammatory bowel disease (IBD) is a heterogeneous group of disorders characterized by the chronic refractory inflamma.tion of gastrointestinal tract, whose development is related to the imbalance of intestinal flora. On the one hand, antibiotics cause intesti.nal flora imbalance and increase the risk of IBD; On the other hand, antibiotics may have a therapeutic effect on IBD by reducing intes.tinal toxins. This article reviews population studies and animal experiments examining the relationship between antibiotic exposure atdifferent stages of life and the development of IBD, and evaluates clinical studies on antibiotic therapy for IBD. |
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