| 董文秀,张明会,张改连.Ⅰ类组蛋白去乙酰化酶在类风湿关节炎中的研究进展[J].安徽医药,2026,30(3):482-486. |
| Ⅰ类组蛋白去乙酰化酶在类风湿关节炎中的研究进展 |
| Research progress of Class Ⅰ histone deacetylases in rheumatoid arthritis |
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| DOI：10.3969/j.issn.1009-6469.2026.03.011 |
| 中文关键词: 关节炎，类风湿 组蛋白脱乙酰酶 组蛋白乙酰转移酶 滑膜成纤维细胞 组蛋白去乙酰化酶抑制剂 |
| 英文关键词: Arthritis, rheumatoid Histone deacetylase Histone acetyltransferases Synovial fibroblast Histone deacetylase in. hibitor |
| 基金项目:山西省留学人员科技活动择优资助项目( 20210003) |
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| 中文摘要: |
| 类风湿关节炎( RA)是以滑膜炎及血管翳形成为特征的风湿免疫病，发病率高、致残性强、预后差，可引起关节损毁，严重影响病人生活质量，给病人带来巨大痛苦。 RA的发病与遗传、环境等多种因素相关。组蛋白乙酰化修饰是表观遗传学中的重要机制之一。组蛋白去乙酰化酶( HDACs)对组蛋白乙酰化修饰的调控发挥重要作用。 Ⅰ类 HDACs在 RA病人中存在表达失调，针对 Ⅰ类 HDACs的抑制剂能够抑制 RA的滑膜增生以及炎症细胞因子的浸润。以 Ⅰ类 HDACs为靶点的药物有望为 RA病人提供新的治疗选择。该文就近年来 Ⅰ类 HDACs在 RA的相关研究进行综述。 |
| 英文摘要: |
| Rheumatoid arthritis (RA) is a rheumatoid immune disease characterized by synovitis and pannus. It has a high incidence,strong disability and poor prognosis, which may cause joint damage, seriously affect the quality of life of patients and bring great pain topatients. The pathogenesis of RA is related to many factors such as heredity and environment. Histone acetylation modification is one ofthe important mechanisms in epigenetics. Histone deacetylases (HDACs) play an important role in the regulation of histone acetylationmodification. Class Ⅰ HDACs are dysregulated in RA patients, and Class Ⅰ HDACs inhibitors can inhibit synovial hyperplasia and in.flammatory cytokine infiltration in RA. Drugs targeting Class Ⅰ HDACs are expected to provide new treatment options for RA patients.This paper reviews the recent research on Class Ⅰ HDACs in RA. |
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