| 杨冬,崔湘君,周彬,等.振幅整合脑电图联合血清神经丝蛋白 H磷酸化亚型、 S100β蛋白对新生儿黄疸脑损伤的早期预测价值[J].安徽医药,2026,30(3):524-528. |
| 振幅整合脑电图联合血清神经丝蛋白 H磷酸化亚型、 S100β蛋白对新生儿黄疸脑损伤的早期预测价值 |
| Early predictive value of amplitude-integrated electroencephalography combined with serum phosphorylated neurofilament heavy subunit and S100β protein for brain injury in neonatal jaundice |
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| DOI：10.3969/j.issn.1009-6469.2026.03.018 |
| 中文关键词: 黄疸，新生儿 脑损伤 振幅整合脑电图 神经丝蛋白 H磷酸化亚型 S100β蛋白 |
| 英文关键词: Jaundice, neonatal Brain injury Amplitude-integrated electroencephalography Phosphorylated neurofilament heavy subunit S100β protein |
| 基金项目:江苏省妇幼健康项目( F202156)；徐州市卫生健康委科技项目( XWKYHT20210536)；徐州市医学领军人才培养项目( XWRCHT20210039) |
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| 中文摘要: |
| 目的探究振幅整合脑电图( aEEG)联合血清神经丝蛋白 H磷酸化亚型( pNF-H)、 S100β蛋白对新生儿黄疸病儿脑损伤的早期预测价值。方法收集 2022年 1月至 2024年 3月徐州市中心医院收治的足月新生儿黄疸病儿 230例，根据胆红素致神经功能障碍( BIND)评估量表评分情况分为无脑损伤者( 0分) 170例为对照组，脑损伤者( 1~9分) 60例为研究组，均行 aEEG动态监测，急性期血清 pNF-H、S100β蛋白水平检测。分析对照组和研究组的 aEEG监测结果以及血清 pNF-H和 S100β蛋白水平，比较单独使用和联合应用这些指标在早期预测新生儿黄疸脑损伤方面的价值。结果 aEEG背景活动的异常程度与新生儿黄疸病儿的脑损伤程度存在正相关关系( P<0.001)。与对照组急性期血清 pNF-H(45.25±8.74)μg/L、S100β蛋白( 96.31±37.37)ng/L相比，研究组 pNF-H(65.87±13.42)μg/L、S100β蛋白( 228.38±52.30)ng/L明显升高(均 P<0.001)；且与新生儿黄疸病儿脑损伤的发生呈正相关。三者联合诊断预测受试者操作特征曲线( ROC曲线)下面积分析显示，三者联合显著大于单独检测 aEEG及 pNF-H、S100β蛋白水平。结论结合 aEEG动态监测与血清 pNF-H、S100β蛋白的检测，有助于更准确地进行新生儿黄疸脑损伤的早期预测。 |
| 英文摘要: |
| Objective To explore the early predictive value of amplitude-integrated electroencephalography (aEEG) combined with serum phosphorylated neurofilament heavy subunit (pNF-H) and S100β protein in brain injury in children with neonatal jaundice. Methods A total of 230 full-term neonates with hyperbilirubinemia admitted to Xuzhou Central Hospital from January 2022 to March2024 were collected. According to the bilirubin-induced neurological dysfunction (BIND) assessment scale, they were divided into a control group (n=170) without brain injury (0 point) and a study group (n=60) with brain injury (1-9 points). All neonates underwent dy. namic aEEG monitoring and measurement of acute-phase serum PNF-H and S100β protein levels. The aEEG monitoring results and se. rum pNF-H and S100β protein levels were analyzed for both groups, and the value of using these indicators individually versus in com.bination for the early prediction of brain injury in neonatal jaundice was compared.Results The abnormality of aEEG background ac.tivity showed a significant positive correlation with the severity of brain injury in neonates with jaundice (P<0.001). Compared with the control group with acute-phase serum levels of pNF-H [(45.25±8.74) μg/L] and S100β protein [(96.31±37.37) ng/L], the study group had significantly higher levels of pNF-H [(65.87±13.42) μg/L] and S100β protein [(228.38±52.30) ng/L] (both P<0.001); these levelswere positively correlated with the occurrence of brain injury in jaundiced neonates. Receiver operating characteristic curve (ROCcurve) analysis for the combined diagnosis of the three markers showed that the area under the curve (AUC) for the combination was sig.nificantly greater than that for aEEG, pNF-H or S100β protein alone.Conclusion Combining dynamic aEEG monitoring with serum pNF-H and S100β protein testing can facilitate more accurate early prediction of brain injury in neonates with jaundice. |
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