| 杨璐菲,查洪,曹荻.无锡地区早产儿视网膜病变发病情况及发生风险临界值初探[J].安徽医药,2026,30(3):580-584. |
| 无锡地区早产儿视网膜病变发病情况及发生风险临界值初探 |
| A preliminary study on the incidence and critical value of risk factors for retinopathy of prematurity in Wuxi area |
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| DOI：10.3969/j.issn.1009-6469.2026.03.030 |
| 中文关键词: 早产儿视网膜病 发病率 出生体重 出生胎龄 无锡 |
| 英文关键词: Retinopathy of prematurity Incidence rate Birth weight Gestational age Wuxi |
| 基金项目:无锡市科协 2025年软科学研究课题( KX-25-C314) |
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| 中文摘要: |
| 目的分析无锡地区早产儿视网膜病变(ROP)的发病情况，探讨发生 ROP风险的预测临界值。方法选取 2020年 1月至 2024年 12月在无锡市妇幼保健院新生儿重症监护室( NICU)住院及该市其他二级医院转至该院眼科门诊、出生体重( BW)≤ 2 000 g或出生胎龄( GA)≤34周的新生儿作为研究对象，采用数字广域眼底成像系统进行眼底视网膜检查，对其临床资料及 ROP筛查结果进行统计分析。结果 5年共 1 568例新生儿接受 ROP筛查，确诊 ROP 109例， ROP发病率为 6.95%，5年间发病率差异有统计学意义(P=0.002)。ROP组 BW［1 120(875，1 355)g比 1 780(1 480，1 970)g］及 GA［28.57(26.93，30.36)周比 33.00(31.29，34.00)周］均显著低于非 ROP组(均 P<0.001)。将 1 568例新生儿分别按 BW、GA升序排列，前者以 300 g、后者以 3周为组距分组，经 χ2检验显示各组间 ROP发病率差异有统计学意义( P<0.001)。受试者操作特征曲线( ROC曲线)分析显示， BW和 GA预测 ROP发病的曲线下面积( AUC)皆为 0.84，约登指数最大时对应的 BW和 GA最佳临界值候选范围分别为 1 350~1 400 g和 30~31周。结论无锡地区 ROP发病率与 BW和 GA密切相关， BW和 GA越低， ROP发病风险越高。 BW<1 350 g或 GA<30周是 ROP发生的重要危险因素，二者对 ROP均具有良好的预测效能。 |
| 英文摘要: |
| Objective To analyze the incidence of retinopathy of prematurity (ROP) in the Wuxi area and to explore the predictivecutoff value for the risk of ROP occurrence.Methods Preterm infants who were hospitalized in the Neonatal Intensive Care Unit (NI.CU) of Wuxi Maternity and Child Health Care Hospital, as well as those transferred to ophthalmology outpatient department of the samehospital from other secondary-level hospitals in the city from January 2020 to December 2024, with a birth weight (BW)≤2 000 g or agestational age (GA)≤34 weeks were selected as the research subjects. A digital wide-field fundus imaging system was used for fundusretinal examination, and statistical analysis was conducted on their clinical data and ROP screening results.Results A total of 1 568 neonates underwent ROP screening over 5 years, among whom 109 cases were diagnosed with ROP, resulting in an ROP incidence rateof 6.95%. The difference in incidence rate over the 5-year period was statistically significant (P=0.002). Both the birth weight (BW) [1 120 (875, 1 355) g vs. 1 780 (1 480, 1 970) g] and gestational age (GA) [28.57 (26.93, 30.36) w vs. 33.00 (31.29, 34.00) w] in the ROP group were significantly lower than those in the non-ROP group (both P<0.001). The 1 568 neonates were sorted in ascending order byBW and GA respectively. For BW, the grouping interval was 300 grams, while for GA, it was 3 weeks. Chi-square test results showed that there were significant statistical differences in ROP incidence rates among the groups (P<0.001). Receiver operating characteristiccurve (ROC curve) analysis showed that the area under the curve (AUC) for both BW and GA in predicting the onset of ROP was 0.84.The optimal cutoff values for BW and GA corresponding to the maximum Youden index were 1 350-1 400 g and 30-31 weeks, respec. tively.Conclusions The incidence rate of ROP in Wuxi Area is closely related to BW and GA. The lower BW and GA, the higher therisk of developing ROP. BW≤1 350 g or GA≤30 weeks are important risk factors for ROP, which have good predictive value for ROP. |
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