| 刘艳琼,张泽英,金红燕,等.角膜塑形镜联合低浓度阿托品对低中度近视病人泪膜、眼压及角膜内皮细胞的影响[J].安徽医药,2026,30(3):614-617. |
| 角膜塑形镜联合低浓度阿托品对低中度近视病人泪膜、眼压及角膜内皮细胞的影响 |
| The effects of corneal reshaping mirror combined with low-concentration atropine on tear film, intraocular pressure, and corneal endothelial cells in patients with low to moderate myopia |
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| DOI：10.3969/j.issn.1009-6469.2026.03.037 |
| 中文关键词: 近视 表面角膜镜片术 角膜塑形镜 阿托品 泪膜 眼压 角膜内皮细胞 |
| 英文关键词: Myopia Epikeratophakia Corneal reshaping mirror Atropine Tear film Eye pressure Corneal endothelial cells |
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| 中文摘要: |
| 目的探讨角膜塑形( OK)镜联合低浓度阿托品对低中度近视病人泪膜、眼压及角膜内皮细胞的影响。方法将 2021年 8月至 2022年 5月攀枝花学院附属医院收治的 86例低中度近视病人( 86右眼)以随机数字表法分为 OK组( n=43)和 OKA组(n=43)，两组病人均配戴 OK镜， OKA组在配戴 OK镜基础上联合使用 0.01%阿托品治疗。治疗 18个月后，比较两组病人裸眼视力、屈光度、眼轴长度、眼压、泪膜［泪膜脂质层厚度( LLT)、泪膜破裂时间( BUT)］、角膜内皮细胞［角膜内皮细胞密度( CD)、六角形细胞( HEX)百分比、细胞面积变异系数( CV)］及角膜损伤情况(角膜染色 Efron分级)。结果治疗后两组病人裸眼视力和屈光度较治疗前均有明显改善( P<0.05)且 OKA组治疗前后裸眼视力矫正差值( 0.66±0.23)LogMAR大于 OK组( 0.56±0.20)LogMAR，屈光度、眼轴长度、 LLT和 BUT差值均小于 OK组( P<0.05)；与 OK组比较，治疗后 OKA组病人 CD、HEX百分比、细胞面积 CV变化差值以及眼压变化、角膜染色 Efron分级均差异无统计学意义( P>0.05)。结论 OK镜联合低浓度阿托品可有效减缓低中度近视进展，改善病人裸眼视力，控制屈光度，延缓眼轴增长速度，且不影响眼压、泪膜功能和角膜内皮细胞，变化，安全性良好。 |
| 英文摘要: |
| Objective To investigate the effects of corneal reshaping (OK) lenses combined with low-concentration atropine on tear film, intraocular pressure, and corneal endothelial cells in patients with low to moderate myopia.Methods Eighty-six patients with lowto moderate myopia (86 right eyes) admitted to Affiliated Hospital of Panzhihua University from August 2021 to May 2022 were random.ly assigned into an OK group (n=43) or an OKA group (n=43) using a random number table method. Both groups of patients wore OKlenses, while the OKA group was treated additionally with a combination of 0.01% atropine. After 18 months of treatment, we comparednaked eye visual acuity, refractive index, axial length, intraocular pressure, tear film [tear film lipid layer thickness (LLT), tear filmbreakup time (BUT)], corneal endothelial cell [corneal endothelial cell density (CD), percentage of hexagonal cells (HEX), coefficient ofvariation (CV) of cell area], and corneal injury (Efron grading of corneal staining) between two groups of patients.Results After treat. ment, both groups of patients showed significant improvement in naked eye vision and refractive index compared with before treatment(P<0.05), and the difference in corrected naked eye vision before and after treatment in the OKA group was greater than that in the OKgroup [(0.66±0.23) LogMAR vs. (0.56±0.20) LogMAR], and the differences in refractive index, axial length, LLT, and BUT changeswere smaller than that in the OK group (P<0.05). Compared with the OK group, there were no statistically significant differences in thechanges of CD, percentage of HEX, CV of cell area, changes in intraocular pressure and corneal staining Efron grading in patients of theOKA group after treatment (P>0.05).Conclusion The combination of OK lenses and low-concentration atropine can effectively slowdown the progression of low to moderate myopia, improve naked eye vision, control refractive error, delay axial growth rate, and do not af.fect intraocular pressure, tear film function, or corneal endothelial cells, and thus has good safety. |
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