| 王长英,曹平.宫颈中肾管腺癌伴股骨转移 1例并文献复习[J].安徽医药,2026,30(3):618-620. |
| 宫颈中肾管腺癌伴股骨转移 1例并文献复习 |
| Mesonephric adenocarcinoma of the cervix with femoral metastasis: a case report and literature review |
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| DOI：10.3969/j.issn.1009-6469.2026.03.038 |
| 中文关键词: 宫颈肿瘤 中肾管腺癌 股骨转移 阴道不规则出血 中肾样腺癌 Kirsten大鼠肉瘤病毒癌基因同源物 |
| 英文关键词: Uterine cervical neoplasms Mesonephric adenocarcinoma Femoral metastasis Irregular vaginal bleeding Meso. nephric-like adenocarcinomas Kirsten rat sarcoma viral oncogene homolog |
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| 中文摘要: |
| 目的探索宫颈中肾管腺癌伴股骨转移的诊疗经验。方法分析湖北医药学院附属襄阳市第一人民医院 2022年 8月收治的 1例伴股骨转移的宫颈中肾管腺癌的临床特征、免疫组织化学、治疗方案，并复习相关文献，了解该病基因突变特点及预后。结果女性， 63岁，以阴道不规则出血为表现。阴道超声提示宫腔新生物，行腹腔镜经腹全子宫 +右侧附件 +盆腔淋巴结切除术。术后病理组织经镜检及免疫组织化学检测诊断为子宫颈体交界处中肾管腺癌，术后行右大腿磁共振成像示:右侧股骨中上段异常信号，考虑为转移病灶，行紫杉醇联合卡铂化疗 1周期，至今随访 16个月，疾病无进展。结论宫颈中肾管腺癌伴股骨转移诊断依赖病理组织形态、免疫组织化学和分子检测，治疗方案参考宫颈腺癌，治疗方式取决于疾病的分期，主要通过手术治疗，也包括化疗和放疗。 |
| 英文摘要: |
| Objective To explore the diagnosis and treatment of cervix mesonephric adenocarcinoma with femoral metastasis.Meth. ods We analyzed the clinical characteristics, immunohistochemistry and treatment regimen of a patient with cervix mesonephric ade.nocarcinoma and femoral metastasis admitted to Xiangyang No.1 People's Hospital Affiliated with Hubei University of Medicine, in Au.gust 2022. A review of relevant literature was also conducted to understand the gene mutation profile and prognosis of this disease.Re. sults A 63-year-old woman presented with irregular vaginal bleeding. Transvaginal ultrasound indicated an intracavitary neoplasm,prompting a laparoscopic total abdominal hysterectomy, right salpingo-oophorectomy, and pelvic lymphadenectomy. Postoperative histo.pathological and immunohistochemical examinations diagnosed mesonephric adenocarcinoma at the cervicouterine junction. Postopera.tive MRI of the right thigh showed abnormal signals in the mid-to-upper segment of the right femur, suggestive of metastatic lesions.The patient received one cycle of paclitaxel plus carboplatin chemotherapy. At 16 months follow-up, the disease has shown no progres. sion.Conclusions The diagnosis of cervical mesonephric adenocarcinoma with femoral metastasis relies on histomorphology, immuno.histochemistry, and molecular testing. Treatment is modeled on that for cervical adenocarcinoma, with the approach determined by dis.ease stage; it primarily involves surgery and may include chemotherapy and radiotherapy. |
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