| 张娟,王平,张越.清热化瘀方辅助治疗湿热瘀结型盆腔炎性疾病后遗症的效果观察[J].安徽医药,2026,30(3):620-624. |
| 清热化瘀方辅助治疗湿热瘀结型盆腔炎性疾病后遗症的效果观察 |
| Effect of Qingre Huayu decoction as adjuvant therapy for sequelae of pelvic inflammatory disease with damp-heat stasis pattern |
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| DOI：10.3969/j.issn.1009-6469.2026.03.039 |
| 中文关键词: 盆腔炎性疾病后遗症 清热化瘀方 湿热瘀结型 免疫状态 血管内皮相关因子 |
| 英文关键词: Sequelae of pelvic inflammatory disease Qingre Huayu decoction Damp-heat stasis pattern Immune status Vas. cular endothelial-related factors |
| 基金项目:河南省中医药科学研究专项课题( 20-21ZY2071) |
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| 中文摘要: |
| 目的探讨清热化瘀方辅助治疗湿热瘀结型盆腔炎性疾病后遗症( SPID)的效果。方法选取 2020年 2月至 2023年 4月郑州市中医院 80例湿热瘀结型 SPID中度病人，按随机数字表法分为常规组与试验组，各 40例。常规组予以左氧氟沙星联合甲硝唑，试验组于此基础上配合清热化瘀方。两组均治疗 4周。比较两组治疗 4周临床疗效，治疗前、治疗 2周、治疗 4周症状改善情况、免疫状态指标［自然杀伤(NK)细胞、 CD3+CD4+/CD8+］、炎症指标［白细胞介素 -8(IL-8)、超敏 C反应蛋白(hs-CRP)、肿瘤坏死因子 α(TNF-α)］、血管内皮相关因子［基质金属、蛋白酶 -2(MMP-2)、细胞间黏附分子 -1(ICAM-1)、血管细胞黏附分子 -1(VCAM-1)］以及治疗期间不良反应。结果试验组与常规组临床治愈、显效、有效、无效病人分别为 9、16、13、2例与 4、12、 15、9例，试验组，疗效优于常规组( P<0.05)；治疗 2周及 4周试验组主症、次症及总积分低于常规组( P<0.05)；治疗 2周及 4周试验组 NK细胞、 CD3+、CD4+/CD8+高于常规组( P<0.05)；治疗 2周及 4周试验组 TNF-α、IL-8、hs-CRP、MMP-2、ICAM-1、VCAM-1水 平低于常规组( P<0.05)；试验组不良反应发生率 17.50%(7/40)与常规组 12.50%(5/40)比较，差异无统计学意义( P>0.05)。结论清热化瘀方辅助治疗湿热瘀结型 SPID可明显减轻病人临床症状、炎症损伤，纠正免疫紊乱状态，改善血管内皮功能，增强疗效，安全可靠。 |
| 英文摘要: |
| Objective To evaluate the efficacy of Qingre Huayu decoction as an adjuvant therapy for sequelae of pelvic inflammatory disease (SPID) presenting with the damp-heat stasis pattern.Methods Eighty patients with moderate SPID of the damp-heat stasis pat.tern treated at Zhengzhou Hospital of Traditional Chinese Medicine between February 2020 and April 2023 were enrolled and random.ly assigned to a conventional group (n=40) or an experimental group (n=40) using a random number table. The conventional group re.ceived levofloxacin combined with metronidazole, while the experimental group received Qingre Huayu decoction in addition to the con. ventional treatment. Both groups were treated for 4 weeks. Clinical efficacy at 4 weeks, symptom improvement, immune status indica.tors [natural killer (NK) cells, CD3+, CD4+/CD8+], inflammatory markers [interleukin-8 (IL-8), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α (TNF-α)], vascular endothelial-related factors [matrix metalloproteinase-2 (MMP-2), intercellular adhe. sion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)] at baseline, 2 weeks, and 4 weeks, and adverse reactions dur. ing treatment were compared between the two groups.Results The numbers of patients with clinical cured, marked effectiveness, ef.fectiveness, and ineffectiveness were 9, 16, 13, and 2, respectively, in the experimental group, and 4, 12, 15, and 9, respectively, in theconventional group. The experimental group showed superior overall efficacy (P<0.05). At 2 and 4 weeks of treatment, scores for mainsymptoms, secondary symptoms and total scores were significantly lower in the experimental group than in the conventional group (P< 0.05). NK cells, CD3+ and CD4+/CD8+ ratios were significantly higher in the experimental group at both time points (P<0.05). Levels of TNF-α, IL-8, hs-CRP, MMP-2, ICAM-1 and VCAM-1 were significantly lower in the experimental group at 2 and 4 weeks (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the experimental group (17.50%, 7/40)and the conventional group (12.50%, 5/40) (P>0.05).Conclusion As an adjunctive therapy for SPID of the damp-heat stasis pattern, Qingre Huayu decoction can significantly alleviate clinical symptoms and inflammatory injury, correct immune dysregulation, improvevascular endothelial function, enhance therapeutic efficacy, and is safe and reliable. |
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