| 余梦辰,童玲,尚圣兰,等.肾移植术后病人妊娠期用药监护 5例并文献复习[J].安徽医药,2026,30(3):625-628. |
| 肾移植术后病人妊娠期用药监护 5例并文献复习 |
| Medication monitoring during pregnancy in five post-renal transplantation patients and literature review |
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| DOI：10.3969/j.issn.1009-6469.2026.03.040 |
| 中文关键词: 药学服务 肾移植 孕妇 妊娠结局 胎儿 免疫抑制方案 |
| 英文关键词: Pharmaceutical services Renal transplantation Pregnant women Pregnancy outcome Fetus Immunosuppres. sive regimen |
| 基金项目:中国博士后科学基金资助( 2022M713859) |
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| 中文摘要: |
| 目的探讨肾移植术后病人妊娠期间免疫抑制方案的选择及药学监护要点，为临床用药提供参考。方法报告 2018年 10月至 2023年 12月某医院收治的 5例肾移植术后女性 8例次妊娠的过程及结局，结合文献探讨妊娠期免疫抑制方案的选择和药学监护要点。结果 5例 8例次妊娠中，有 4例次成功分娩且随访至今子代发育正常， 4例次在孕早期胚胎停育。不良围生结局可能与使用高致畸、致流产风险药物及病人依从性不佳有关。结论肾移植受者在妊娠期应进行严密的药学监护，综合考虑移植肾功能与母体、胎儿安全，制定个体化的用药方案，以维持移植肾功能正常、改善围生结局。 |
| 英文摘要: |
| Objective To discuss the selection of immunosuppressive regimen and key points of pharmaceutical care for pregnant pa.tients after renal transplantation. Methods This report summarized the processes and outcomes of eight pregnancies in five kidneytransplant recipients at a hospital from October 2018 to December 2023, with discussion on immunosuppressive regimen selection anddrug monitoring, supported by literature review.Results Among the cases studied, four pregnancies resulted in successful deliveries,and the offspring have developed normally thus far. However, four pregnancies ended in early miscarriage. Adverse perinatal outcomesmay be associated with the use of drugs that have a high teratogenic risk or an increased risk of miscarriage, and poor patient compli.ance.Conclusions Renal transplant recipients should receive comprehensive pharmaceutical care during pregnancy. An individual.ized medication regimen should be developed, taking into account the safety of the kidneys, the mother, and the fetus, in order to pro.tect renal function and improve perinatal outcomes. |
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