| 崔琳杰,梁霜,宋卿.肿瘤相关巨噬细胞对大肠癌转移的影响及其中医药干预机制研究[J].安徽医药,2026,30(4):670-675. |
| 肿瘤相关巨噬细胞对大肠癌转移的影响及其中医药干预机制研究 |
| Study on the effect of tumor-associated macrophages on colorectal cancer metastasis and its intervention mechanism by traditional Chinese medicine |
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| DOI：10.3969/j.issn.1009-6469.2026.04.007 |
| 中文关键词: 结直肠肿瘤 肿瘤相关巨噬细胞 转移 中医药 机制研究 |
| 英文关键词: Colorectal neoplasms Tumor-associated macrophages Metastasis Traditional Chinese medicine and pharmacy Mechanism study |
| 基金项目:国家自然科学基金项目( 82004136，82274257)；江苏省自然科学基金项目( BK20221246) |
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| 中文摘要: |
| 大肠癌是最常见的消化系统恶性肿瘤之一，其发病率居全球第 3位，病死率居全球第 2位。大肠癌转移是导致病人死亡的主要原因，呈现出预后差、病死率高的特点。肿瘤相关巨噬细胞( tumor associated macrophages，TAMs)的 M2型具有促进肿瘤细胞的增殖、血管生成、侵袭转移和免疫逃逸等功能。而中医药被证实可以通过调控 TAMs，调节机体免疫功能，重塑平衡状态发挥抗肿瘤作用。该研究在阐述 TAMs影响大肠癌转移途径的基础上，探讨中医药( traditional Chinese medicine and pharmacy， TCM)调控 TAMs防治大肠癌转移的研究现状，以期为 TCM抗瘤提供新思路。 |
| 英文摘要: |
| Colorectal cancer is one of the most common malignant tumors of the digestive system, with the third highest incidencerate and the second highest death rate in the world. Metastasis of colorectal cancer is the main cause of patient death, presenting poorprognosis and high morbidity and mortality. The M2 type of tumor associated macrophages (TAMs) has the function of promoting tu-mor cell value-adding, angiogenesis, invasion and metastasis, and immune escape. And Chinese medicine has been proved to play an anti-tumor role by regulating TAMs, modulating the body's immune function, and reshaping the balance state. In this study, based onthe elaboration of TAMs affecting the metastatic pathway of colorectal cancer, we discuss the current research status of TraditionalChinese Medicine (TCM) regulating TAMs to prevent and control colorectal cancer metastasis, with a view to providing new ideas forTCM anti-tumor. |
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