| 李芝明.基于“疏肝健脾”法的针刺疗法对2型糖尿病合并肝郁脾虚型NAFLD患者氧化应激及炎症因子的干预研究[J].安徽医药,待发表. |
| 基于“疏肝健脾”法的针刺疗法对2型糖尿病合并肝郁脾虚型NAFLD患者氧化应激及炎症因子的干预研究 |
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| 投稿时间：2026-04-07 录用日期：2026-05-27 |
| DOI： |
| 中文关键词: 疏肝健脾 针刺 2型糖尿病 肝郁脾虚型 非酒精性脂肪肝 氧化应激 炎症 |
| 英文关键词: |
| 基金项目:2025年度郑州市医疗卫生领域科技创新指导计划项目（编号：2025YLZDJH304） |
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| 中文摘要: |
| 【摘要】目的 探讨基于“疏肝健脾”法的针刺疗法对2型糖尿病（T2DM）合并肝郁脾虚型非酒精性脂肪性肝病（NAFLD）患者的临床疗效。方法 前瞻性选取2023年11月~2025年11月112例郑州人民医院中医科T2DM合并肝郁脾虚型NAFLD患者，以随机数字表法分对照组（n=56）行常规治疗，观察组（n=56）行基于“疏肝健脾”法的针刺疗法。两组治疗前后比较中医证候积分、糖脂代谢、氧化应激、炎症因子及肝功能水平。结果 治疗后，观察组胁肋胀痛、情绪抑郁、食少纳呆、脘腹痞闷证候积分低于对照组（P<0.05）；观察组空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、三酰甘油（TG）低于对照组（P<0.05）；观察组血清超氧化物歧化酶（SOD）及谷胱甘肽过氧化物酶（GSH-Px）高于对照组，丙二醛（MDA）低于对照组（P<0.05）；观察组白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）及超敏C反应蛋白（hs-CRP）低于对照组（P<0.05）；观察组丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)水平低于对照组（P<0.05）。结论 基于“疏肝健脾”法的针刺疗法能有效改善2型糖尿病合并肝郁脾虚型NAFLD患者的糖脂代谢及肝功能，减轻临床症状。其作用机制可能与上调机体抗氧化能力、抑制脂质过氧化反应以及下调IL-6、TNF-α、hs-CRP的表达、减轻肝脏炎性损伤有关。 |
| 英文摘要: |
| 【Abstract】Objective To investigate the clinical effect of acupuncture guided by the principle of soothing the liver and tonifying the spleen on type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease of liver stagnation and spleen deficiency pattern.Method: A total of 112 patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease of liver stagnation and spleen deficiency pattern were prospectively enrolled from the Department of Traditional Chinese Medicine at Zhengzhou People's Hospital between November 2023 and November 2025.Using a random number table, the patients were randomly assigned to either a control group (n=56) receiving conventional treatment or an observation group (n=56) receiving additional acupuncture therapy based on the principle of soothing the liver and invigorating the spleen.TCM syndrome scores, glucose and lipid metabolism indicators, oxidative stress parameters, inflammatory factor levels, and liver function indexes were compared between the two groups before and after intervention.Result Following treatment, the observation group exhibited significantly lower scores for hypochondriac distending pain, emotional depression, anorexia, and epigastric fullness relative to the control group (P<0.05).Levels of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), total cholesterol (TC), and triglyceride (TG) were also notably lower in the observation group (P<0.05).In addition, the observation group presented higher serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, accompanied by lower malondialdehyde (MDA) levels compared with the control group (P<0.05). |
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