| 王柏荣,郭协力,戴伟川,等.2型糖尿病病人血清富含半胱氨酸蛋白 61和应激诱导蛋白 2水平与颈动脉粥样硬化的关系研究[J].安徽医药,2026,30(4):718-722. |
| 2型糖尿病病人血清富含半胱氨酸蛋白 61和应激诱导蛋白 2水平与颈动脉粥样硬化的关系研究 |
| Study on the relationship between serum CYR61 and Sestrin2 levels and carotid atherosclerosis in type 2 diabetes mellitus patients |
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| DOI：10.3969/j.issn.1009-6469.2026.04.016 |
| 中文关键词: 糖尿病血管病变 糖尿病， 2型 动脉粥样硬化 富含半胱氨酸蛋白 61 Sestrin2 颈动脉 糖化血红蛋白 |
| 英文关键词: Diabetic angiopathies Diabetes mellitus, type 2 Atherosclerosis Cysteine-rich Protein 61 Sestrin2 Carotid ar-teries Glycated hemoglobin |
| 基金项目:福建省卫生健康科技计划项目( 2022CXA059) |
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| 中文摘要: |
| 目的探讨 2型糖尿病( T2DM)病人血清富含半胱氨酸蛋白 61(CYR61)、应激诱导蛋白 2(Sestrin2)与颈动脉粥样硬化(CAS)之间的关系。方法选取晋江市医院(上海市第六人民医院福建医院) 2019年 11月至 2021年 11月收治的 136例 T2DM病人为研究对象，根据 T2DM病人是否合并 CAS将病人分为 CAS组(57例)和无 CAS组(NAS组， 79例)，另外选取体检的健康者 88例作为健康组，单因素和多因素 logistic回归分析探索 T2DM病人并发 CAS的影响因素；受试者操作特征曲线(ROC曲线)分析血清 CYR61、Sestrin2水平对 T2DM病人并发 CAS的预测价值。结果糖尿病组血清 CYR61［( 9.65±2.54)μg/L］、 Sestrin2［( 1.68±0.38)μg/L］水平均高于健康组 CYR61［(4.08±1.04)μg/L］、 Sestrin2［(1.14±0.26)μg/L］水平( P<0.05)； CAS组血清 CYR61、Sestrin2水平高于 NAS组(P<0.05)；血清 CYR61、Sestrin2高水平、 T2DM病程增加、收缩压升高、糖化血红蛋白(HbA1c)升高、低密度脂蛋白胆固醇( LDL-C)升高均是 T2DM病人并发 CAS的独立危险因素( P<0.05)；血清 CYR61、Sestrin2水平及二者联合预测 T2DM病人并发 CAS的曲线下面积(AUC)分别为 0.89、0.81、0.94。结论 T2DM病人中血清 CYR61、Sestrin2水平升高，二者水平与 T2DM病人并发 CAS有关，可能是预测 T2DM病人发生 CAS的血清标志物。 |
| 英文摘要: |
| Objective To investigate the relationship between serum cysteine-rich Protein 61 (CYR61), Sestrin2 and carotid athero-sclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 136 patients with T2DM admitted to Jinjiang Mu-nicipal Hospital (Shanghai Sixth People's Hospital Fujian) from November 2019 to November 2021 were enrolled as the study subjects.According to whether T2DM patients had CAS or not, the patients were divided into CAS group (57 cases) and CAS group (NAS group,79 cases). Additionally, 88 healthy individuals from physical examinations were selected as the healthy group. The influencing factorsof T2DM patients complicated with CAS were analyzed by single factor and multiple factor Logistic analyses; the predictive value of se-rum CYR61 and Sestrin2 levels in patients with T2DM complicated with CAS was analyzed by the receiver operating characteristiccurve (ROC curve).Results The serum levels of CYR61 [(9.65±2.54)μg/L] and Sestrin2 [(1.68±0.38) μg/L] in the diabetic group werehigher than CYR61 [(4.08±1.04) μg/L] and Sestrin2 [(1.14±0.26) μg/L] in the healthy control group (P<0.05); the serum levels of CYR61 and Sestrin2 in CAS group were higher than those in NAS group (P<0.05); high levels of serum CYR61 and Sestrin2, increased course of T2DM, elevated SBP, elevated HbA1c and elevated LDL-C were all independent risk factors of CAS in T2DM patients (P< 0.05); serum CYR61 and Sestrin2 levels and their combination predicted the AUC of CAS in T2DM patients were 0.89, 0.81 and 0.94,respectively.Conclusion The levels of CYR61 and Sestrin2 in serum of T2DM patients are increased, which are related to the occur-rence of CAS in T2DM patients, and may be used as serum markers to predict the occurrence of CAS in T2DM patients. |
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