| 周海红,赵志宏,何年安.颈动脉狭窄病人血浆致动脉粥样硬化指数与椎动脉超声血流动力学改变分析[J].安徽医药,2026,30(4):728-732. |
| 颈动脉狭窄病人血浆致动脉粥样硬化指数与椎动脉超声血流动力学改变分析 |
| Analysis of the relationship between the atherogenic index of plasma (AIP) and ultrasonic hemodynamic parameters of vertebral artery in patients with carotid artery stenosis |
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| DOI：10.3969/j.issn.1009-6469.2026.04.018 |
| 中文关键词: 颈动脉狭窄 超声检查，多普勒，彩色 颈动脉内膜中膜厚度 血流速度 甘油三酯 低密度脂蛋白胆固醇 椎动脉 血浆致动脉粥样硬化指数(AIP) 血流动力学 |
| 英文关键词: Carotid stenosis Ultrasonography, doppler, color Carotid intima-media thickness Blood flow velocity Triglycer-ide Low-density lipoprotein cholesterol Vertebral artery Atherogenic index of plasma (AIP) Hemodynamics |
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| 中文摘要: |
| 目的探索颈动脉狭窄病人血浆致动脉粥样硬化指数( atherogenic index of plasma，AIP)与椎动脉超声血流动力学之间的联系。方法该研究为回顾性研究。选取 2023年 1月至 2025年 11月在中国科学技术大学附属第一医院(安徽省立医院)进行颈动脉超声检查的住院病人 173例，采用彩色多普勒超声检测双侧椎动脉内径( vertebral artery，VD)、收缩期峰值流速( peak systolic velocity，PSV)、舒张末期流速( end-diastolic velocity，EDV)及阻力指数( resistance index，RI)。收集检验结果资料与生化指标并计算 AIP，通过 Pearson相关、 logistic回归开展统计分析。结果依据颈动脉血管狭窄超声诊断标准分为颈动脉狭窄(carotid artery stenosis，CAS)组 130例( 75.14%)，非颈动脉狭窄组( non-carotid artery stenosis，NCAS)43例( 24.86%)。 CAS组高密度脂蛋白胆固醇( high-density lipoprotein cholesterol，HDL-C)为( 2.44±1.08)mmol/L，NCAS组 LDL-C为( 1.14±0.28)mmol/L(P<0.001)。 AIP与右椎动脉内径( r=0.29，P<0.001)、 PSV(r=0.21，P=0.005)、 EDV(r=0.26，P<0.001)呈正相关， AIP与右侧椎动脉 RI(r=.0.20，P=0.008)呈负相关；多因素 logistic回归显示低密度脂蛋白胆固醇( low-density lipoprotein cholesterol，LDL-C)［OR=17.99，95%CI:(3.42，94.68)］、冠心病史［ OR=6.35，95%CI:(1.31，30.73)］、右侧椎动脉 PSV［OR=1.09，95%CI:(1.02，1.17)］和 AIP［OR=16.40，95%CI:(1.13，238.93)］是 CAS的独立预测因子(P<0.05)。结论 AIP是颈动脉狭窄病人的较强预测因子，联合椎动脉血流 PSV、LDL-C、冠心病史等特征，为 CAS病人的早期干预及后循环保护提供循证依据。 |
| 英文摘要: |
| Objective To explore the relationship between the atherogenic index of plasma (AIP) and hemodynamic parameters ofvertebral artery assessed by ultrasonography in patients with carotid artery stenosis (CAS).Methods This study is a retrospective in-vestigation.A total of 173 hospitalized patients who underwent carotid artery ultrasonography at The First Affiliated Hospital of Univer-sity of Science and Technology of China (January 2023 to November 2025) were enrolled. Color Doppler ultrasonography was used tomeasure bilateral vertebral artery diameter (VD), peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI).Laboratory and biochemical data were collected to calculate AIP. Pearson correlation analysis and logistic regression were performedfor statistical analysis.Results According to ultrasound diagnostic criteria for carotid artery stenosis, 130 patients (75.14%) were as-signed to the CAS group and 43 patients (24.86%) to the non-CAS (NCAS) group. Low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in the CAS group than those in the NCAS group [(2.44 ± 1.08) mmol/L vs. (1.14 ± 0.28) mmol/L, P < 0.001). AIP was positively correlated with right vertebral artery diameter (r = 0.29, P < 0.001), PSV (r = 0.21, P = 0.005), and EDV (r = 0.26, P < 0.001), and negatively correlated with right vertebral artery RI (r = .0.20, P = 0.008). Multivariable logistic regression analysis re-sults indicated that LDL-C[OR=17.99, 95%CI:(3.42,94.68)], history of coronary heart disease [OR=6.35, 95%CI:(1.31,30.73)], right vertebral artery PSV [OR=1.09, 95%CI:(1.02,1.17)], and AIP [OR=16.40, 95%CI:(1.13,238.93)] were independent predictors of CAS (P < 0.05).Conclusions AIP is a strong predictor of carotid artery stenosis. Combined assessment of AIP, vertebral artery PSV, LDL-C, and history of coronary heart disease may provide valuable evidence for early intervention and posterior circulation protection in pa-tients with CAS. |
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