基于倾向性评分匹配法探究空腹血糖对甲状腺结节发病风险的影响

刘岳楠; 渠鹏霞; 李静; 杨爽; 杨慧; 万琪; 李元宾

文章摘要

刘岳楠,渠鹏霞,李静,等.基于倾向性评分匹配法探究空腹血糖对甲状腺结节发病风险的影响[J].安徽医药,2026,30(4):738-744.

基于倾向性评分匹配法探究空腹血糖对甲状腺结节发病风险的影响

Exploring the effect of fasting blood glucose on the risk of developing thyroid nodules based on a propensity score matching

DOI：10.3969/j.issn.1009-6469.2026.04.020

中文关键词: 甲状腺结节空腹血糖糖尿病倾向性评分匹配法发病风险

英文关键词: Thyroid nodule Fasting blood glucose Diabetes Propensity score matching

基金项目:山西省中医药管理局科研课题项目( 2022ZYYC119)

作者	单位	E-mail
刘岳楠	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
渠鹏霞	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
李静	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
杨爽	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
杨慧	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
万琪	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000
李元宾	山西医科大学第九临床医学院、北京大学第一医院太原医院内分泌科,山西太原 030000 龙岗区第三人民医院内分泌科,广东深圳 518100	liyuanbinl@163.com

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中文摘要:

目的基于倾向性评分匹配法( propensity score matching，PSM)探究太原地区空腹血糖( fasting blood glucose，FBG)水平与甲状腺结节(thyroid nodule，TN)患病率、数量、恶性风险及性质的相关性。方法选取 2020年 10月至 2021年 10月在山西尚宁健康体检中心进行常规体检者 42 704名作为研究对象，收集一般资料、生化检测及甲状腺超声等检查。共纳入 FBG<7 mmol/L者 39 721名， FBG≥7 mmol/L者 2 983名，采用多因素 logistic回归及 PSM法分析 FBG水平与 TN患病率、数量、恶性风险及其性质的关系。结果 FBG<7 mmol/L组甲状腺结节检出率为 54.8%，FBG≥7 mmol/L组甲状腺结节检出率为 66.6%。与无甲状腺结节者相比，有结节者空腹血糖水平更高［(5.73±1.41)mmol/L比( 5.57±1.25)mmol/L，P<0.05］。采用 PSM法对两组进行匹配。 PSM后，在总人群中，与 FBG<7 mmol/L组相比， FBG≥7 mmol/L是 TN发生的危险因素［ OR及其 95％CI:1.17(1.04，1.30)］，也是甲状腺多发结节［ OR及其 95％CI:1.16(1.03，1.31)］实性或囊实性结节［OR及其 95％CI:1.17(1.05，1.31)］的危险因素；男性人群中， FBG≥7 mmol/L是 TN发生的危险因素［ OR及其、95％CI:1.15(1.00，1.31)］，同时也是甲状腺多发结节［OR及其 95％在

英文摘要:

Objective To investigate the correlation between fasting blood glucose (FBG) level and the prevalence, number, risk ofmalignancy and nature of thyroid nodules (TN) in Taiyuan based on the Propensity Score Matching (PSM) method.Method A total of 42,704 people who underwent routine physical examinations at Shang ning Health Check-up Center in Shanxi from October 2020 to Oc-tober 2021 were selected as the research subjects. General information, biochemical test results and thyroid ultrasound results were col-lected. A total of 39,721 patients were included in the FBG < 7 mmol/L group, and 2,983 patients were included in the FBG ≥ 7 mmol/L group. The correlation between FBG level and the prevalence, number, malignancy risk, and properties of TN were analyzed usingmultivariate logistic regression and PSM.Results The prevalence of TN was 54.8% <7 mmol/L group, and 66.6% in the FBG≥7 mmol/L group. Compared with individuals without thyroid nodules, those with nodules had higher fasting plasma glucose levels [(5.73±1.41)mmol/L vs. (5.57±1.25) mmol/L, P<0.05]. The FBG ≥7 mmol/L group and the FBG <7 mmol/L group were matched using PSM. AfterPSM, in the total population, FBG ≥7 mmol/L was a risk factor for the development of TN [OR 95％CI:1.17 (1.04, 1.30)] and for multi-ple thyroid nodules [OR 95％CI:1.16 (1.03, 1.31)], solid or cystic solid nodules [OR 95％CI:1.17 (1.05, 1.31)]; in the male population, FBG ≥7 mmol/L was a risk factor for the development of TN [OR 95％CI:1.15 (1.00, 1.31)], as well as for multiple thyroid nodules [OR 95％CI:1.17 (1.00, 1.36)] and solid or cystic solid nodules [OR 95％CI:1.16 (1.00, 1.33)] risk factors, while none of them were statisti-cally significant in the female population.Conclusions The prevalence of TN is higher in the FBG ≥7 mmol/L group. A high FBG lev-el may be an independent risk factor for the occurrence and number and properties of TN in the male population, regardless of the ma-lignant risk of TN.

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