| 谢静,苏佳,孙思博.血清颗粒蛋白前体、人中性粒细胞肽 1-3对慢性阻塞性肺疾病伴肺部感染的诊断价值[J].安徽医药,2026,30(4):767-770. |
| 血清颗粒蛋白前体、人中性粒细胞肽 1-3对慢性阻塞性肺疾病伴肺部感染的诊断价值 |
| The diagnostic value of serum PGRN and HNP1-3 for chronic obstructive pulmonary disease with pulmonary infection and the distribution of infectious pathogenic bacteria |
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| DOI：10.3969/j.issn.1009-6469.2026.04.025 |
| 中文关键词: 肺疾病，慢性阻塞性 肺部感染 颗粒蛋白前体 人中性粒细胞肽 1-3 病原菌 |
| 英文关键词: Pulmonary disease,chronic obstructive Pulmonary infection Progranulin Human neutrophil peptide 1-3 Patho-genic bacteria |
| 基金项目:宿迁市科技计划项目( K202242) |
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| 中文摘要: |
| 目的探究血清颗粒蛋白前体( PGRN)、人中性粒细胞肽 1-3(HNP1-3)对慢性阻塞性肺疾病( COPD)伴肺部感染的诊断价值以及感染病原菌的分布。方法回顾性选取 2023年 3月至 2024年 3月在宿迁市第一人民医院就诊的 80例 COPD病人，依据是否出现肺部感染分为感染组和未感染组。比较感染组与未感染组 COPD病人血清 PGRN、HNP1-3水平及一般资料； logis-tic回归分析影响因素；受试者操作特征曲线( ROC曲线)评估诊断价值；分析感染组的病原菌分布情况。结果感染组血清 PGRN、HNP1-3水平［(224.21±26.29)μg/L、(2.56±0.41)ng/L］高于未感染组［(181.26±23.15)μg/L、(1.87±0.29)ng/L］(P<0.05)；吸烟史、糖尿病病史、 COPD分级 Ⅱ/Ⅲ及血清 PGRN、HNP1-3水平升高均是 COPD并发肺部感染的危险因素( P<0.05)；血清 PGRN、HNP1-3检测 COPD伴肺部感染的曲线下面积( AUC)分别为 0.88、0.88，二者联合的 AUC为 0.96，明显优于血清 PGRN、 HNP1-3单独检测( Z二者联合 -PGRN=2.09，P=0.036；Z二者联合 -HNP1-3=2.36，P=0.018)； COPD伴肺部感染的呼吸道痰液样本中分离出 38株病原菌，革兰阴性菌( 27株， 71.04%)，革兰阳性菌( 7株， 18.43%)真菌( 4株， 10.53%)。结论血清 PGRN、HNP1-3表达可用于诊断 COPD伴肺部感染，且二者联合诊断效能较高； COPD伴肺部感，染病原菌主要为革兰阴性菌、革兰阳性菌，少量真菌。 |
| 英文摘要: |
| Objective To explore the diagnostic value of serum progranulin (PGRN) and human neutrophil peptide 1-3 (HNP1-3) for chronic obstructive pulmonary disease (COPD) with pulmonary infection, and the distribution of infectious pathogenic bacteria.Meth. ods Eighty COPD patients who were treated in Suqian First People's Hospital from March 2023 to March 2024 were retrospectivelyselected, and were assigned into an infected group and an uninfected group based on whether they had pulmonary infections. The serumlevels of PGRN and HNP1-3, and general information were compared between the infected group and uninfected group. Logistic regres-sion was used to analyze influencing factors; ROC curve was used to evaluate diagnostic value; the distribution of pathogenic bacteria inCOPD patients in the infected group was analyzed.Results The levels of serum PGRN and HNP1-3 in the infected group [(224.21±26.29) μg/L, (2.56±0.41) ng/L] were higher than those in the uninfected group [(181.26±23.15) μg/L, (1.87±0.29) ng/L] (P<0.05). Smoking history, history of diabetes, COPD grade Ⅱ/Ⅲ, and elevated serum levels of PGRN and HNP1-3 were all risk factors for pul-monary infection in COPD patients (P<0.05). The area under the curve (AUC) of serum PGRN and HNP1-3 detection for COPD with pulmonary infection was 0.876 and 0.878, respectively. The AUC of the combination of the two was 0.958, which was obviously betterthan serum PGRN and HNP1-3 alone detection (Zcombination -PGRN=2.09, P=0.036; Zcombination -HNP1-3=2.36, P=0.018). A total of 38 pathogenicbacteria were isolated from respiratory sputum samples of COPD patients with pulmonary infection, including 27 Gram negative bacte-ria, accounting for 71.04%; 7 strains of Gram positive bacteria, accounting for 18.43%; 4 strains of fungi, accounting for 10.53%.Con. clusions The expression of serum PGRN and HNP1-3 may be used for the diagnosis of COPD with pulmonary infection, and theircombined diagnostic efficacy is high. The main pathogenic bacteria in COPD with pulmonary infection patients are Gram negative andGram positive bacteria, with a small amount of fungi. |
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