| 朱小涛,杨松.血清血管性血友病因子、基质金属蛋白酶 -9、葡萄糖调节蛋白 78联合检测对急性胰腺炎病人预后价值的初步研究[J].安徽医药,2026,30(4):795-799. |
| 血清血管性血友病因子、基质金属蛋白酶 -9、葡萄糖调节蛋白 78联合检测对急性胰腺炎病人预后价值的初步研究 |
| A preliminary study on the prognostic value of combined detection of serum vWF, MMP-9, and GRP78 in patients with acute pancreatitis |
| |
| DOI：10.3969/j.issn.1009-6469.2026.04.031 |
| 中文关键词: 急性胰腺炎 血管性血友病因子 基质金属蛋白酶 -9 葡萄糖调节蛋白 78 预后 |
| 英文关键词: Acute pancreatitis Von Willebrand factor Matrix metalloproteinase-9 Glucose regulated protein 78 Prognosis |
| 基金项目: |
|
| 摘要点击次数: 184 |
| 全文下载次数: 123 |
| 中文摘要: |
| 目的探究血清血管性血友病因子( vWF)、基质金属蛋白酶 -9(MMP-9)、葡萄糖调节蛋白 78(GRP78)联合检测对急性胰腺炎病人预后的预测价值。方法选取 126例在重庆市武隆区人民医院 2021年 9月至 2023年 9月收治的急性胰腺炎病人作为研究组，根据亚特兰大分类将其分为轻症组( n=57)、中症组( n=50)、重症组( n=19)；根据预后状况分为预后不良组( n= 34)、预后良好组( n=92)；另选取 126例在该院进行健康体检者作为健康组。用 ELISA法检测血清 vWF、MMP-9、GRP78水平；病人预后的影响因素用多因素 logistic回归分析；血清 vWF、MMP-9、GRP78对病人预后的预测价值用受试者操作特征曲线(ROC曲线)分析。结果研究组血清 vWF［( 203.81±26.60)%比( 179.27±21.08)%］、 MMP-9［( 376.86±50.41)μg/L比( 331.25±42.23)μg/L］、 GRP78［( 376.63±47.17)μg/L比( 323.58±52.85)μg/L］水平均显著高于健康组( P<0.05)；重症组血清 vWF、MMP-9、 GRP78表达水平均显著高于轻症组、中症组，且中症组血清 vWF、MMP-9、GRP78表达水平均高于轻症组(P<0.05)；预后不良组急性生理学和慢性健康状况评价 Ⅱ(APACHEⅡ)评分、血清 CRP、vWF、MMP-9、GRP78水平均显著高于预后良好组( P<0.05)；血清 vWF、MMP-9、GRP78、APACHEⅡ评分为急性胰腺炎病人预后的影响因素( P<0.05)；血清 vWF、MMP-9、GRP78联合预测急性胰腺炎病人预后的曲线下面积( AUC)为 0.93，高于各自单一检测( Z二者联合 -MMP-9=2.38，P=0.011；Z二者联合 -vWF=2.56，P=0.017； Z二者联合 -GRP78=2.64，P=0.008)。结论急性胰腺炎病人血清 vWF、MMP-9、GRP78表达水平均明显升高，其水平升高对预后有一定参考作用，三者联合检测对急性胰腺炎病人预后有更高的预测价值。 |
| 英文摘要: |
| Objective To explore the predictive value of combined detection of serum von Willebrand factor (vWF), matrix metallo-proteinase-9 (MMP-9), and glucose regulated protein 78 (GRP78) for the prognosis of patients with acute pancreatitis.Methods A to-tal of 126 patients with acute pancreatitis, who were admitted to Chongqing Wulong District People's Hospital from September 2021 toSeptember 2023, were regarded as the treatment group. According to the Atlanta classification, they were assigned to mild group (n= 57), moderate group (n=50), or severe group (n=19); according to the prognosis, they were assigned to good prognosis group (n=92) or poor prognosis group (n=34); meanwhile, 126 individuals who underwent health examinations in the same hospital were included as thecontrol group. ELISA was applied to detect serum vWF, MMP-9, and GRP78 levels; multivariate Logistic regression was applied to ana-lyze the risk factors for the prognosis of patients with acute pancreatitis; ROC curve was applied to analyze the predictive value of se-rum vWF, MMP-9, and GRP78 for the prognosis.Results The levels of serum vWF [(203.81±26.60) % vs. (179.27±21.08) %], MMP-9 [(376.86±50.41) μg/L vs. (331.25±42.23) μg/L], and GRP78 [(376.63±47.17) μg/L vs. (323.58±52.85) μg/L] in the treatment group were significantly higher than those in the control group (P<0.05). The expression levels of serum vWF, MMP-9, and GRP78 in the se-vere group were significantly higher than those in the mild and moderate groups, and the expression levels of serum vWF, MMP-9, and GRP78 in the moderate group were higher than those in the mild group (P<0.05). The APACHEⅡ score, serum CRP, vWF, MMP-9, and GRP78 levels in the poor prognosis group were all significantly higher than those in the good prognosis group (P<0.05). Serum vWF, MMP-9, GRP78, and APACHEⅡ score were prognostic factors for patients with acute pancreatitis (P<0.05). The area under the curve (AUC) of the combined prediction of serum vWF, MMP-9, and GRP78 for prognosis in patients with acute pancreatitis was 0.93,which was higher than the individual detection of serum vWF, MMP-9, and GRP78 (Zcombined prediction -MMP-9=2.38, P=0.011; Zcombined prediction -vWF =2.56, P=0.017; Zcombined prediction-GRP78=2.64, P=0.008).Conclusion The expression levels of serum vWF, MMP-9, and GRP78 in patientswith acute pancreatitis are significantly increased, which has certain prognostic value, and the combined detection of the three has ahigher value in patients with acute pancreatitis. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
