| 王雅钗,秦艳玲,李倩男.清热解毒方联合西医治疗热毒炽盛证银屑病疗效及对血清炎症因子的影响[J].安徽医药,2026,30(4):830-834. |
| 清热解毒方联合西医治疗热毒炽盛证银屑病疗效及对血清炎症因子的影响 |
| Therapeutic effect of Qingre Jiedu formula combined with western medicine on psoriasis of exuberant heat toxin pattern type and its impact on serum inflammatory factors |
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| DOI：10.3969/j.issn.1009-6469.2026.04.038 |
| 中文关键词: 银屑病 清热解毒方 临床疗效 炎症因子 热毒炽盛证 |
| 英文关键词: Psoriasis Qingre Jiedu formula Clinical efficacy Inflammatory factors Intense Heat-Toxin Pattern |
| 基金项目:中医药类科学研究课题计划项目( 2023445) |
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| 中文摘要: |
| 目的探究清热解毒方联合西医治疗热毒炽盛证银屑病疗效及对血清炎症因子的影响。方法选取 2022年 4月至 2023年 2月于河北省沧州中西医结合医院就诊的 96例热毒炽盛证银屑病病人，采用随机数字表法分为对照组(阿维 A胶囊 +卡泊三醇软膏， 48例)和实验组(阿维 A胶囊 +卡泊三醇软膏 +清热解毒方， 48例)比较两组临床疗效、银屑病面积和严重程度指数(PASI)炎症和免疫功能、生长因子水平和不良反应。结果实验组临床总有效，率( 95.83%)显著超过对照组( 77.08%)(P< 0.05)；实验组各、项 PASI评分显著低于对照组( P<0.05)；治疗后对照组与实验组白细胞介素 -6(IL-6)比较差异有统计学意义［( 4.79±1.04)ng/L比( 3.42±0.95)ng/L］，肿瘤坏死因子 α(TNF-α)、分化抗原( CD)8+下降和 CD3+、CD4+、CD4+/CD8+上升幅度均不及实验组显著( P<0.05)；实验组的血管内皮生长因子( VEGF)、神经生长因子( NGF)和转化生长因子 β1(TGF-β1)水平均低于对照组( P<0.05)；实验组不良反应( 4.17%)较对照组( 22.92%)显著更低( P<0.05)。结论清热解毒方联合西医治疗能有效增强热毒炽盛证银屑病病人的临床疗效，降低血清炎症因子水平。 |
| 英文摘要: |
| Objective To explore the therapeutic effect of Qingre Jiedu formula combined with western medicine in the treatment of psoriasis of exuberant heat toxin pattern type and its impact on serum inflammatory factors.Methods A total of 96 patients with psori-asis of exuberant heat toxin pattern type who were treated in Cangzhou Hospital of Integrated TCM-WM·Hebei from April 2022 to Feb-ruary 2023 were assigned to control group (acitrium A capsule + capotriol ointment, 48 cases) or experimental group (acitrium A cap-sule + capotriol ointment + Qingre Jiedu prescription, 48 cases) by random number table method. The clinical efficacy, psoriasis areaand severity index (PASI), inflammation and immune function, growth factor levels and adverse reactions were compared between thetwo groups.Results The total clinical effective rate of experimental group was significantly higher than that of control group (95.83% vs. 77.08, P<0.05). PASI scores in experimental group were significantly lower than those in control group (P<0.05). After treatment, the difference in interleukin-6 (IL-6) [(4.79±1.04) ng/L vs. (3.42±0.95) ng/L] was statistically significant between the two groups. Com-pared with experimental group, control group showed significantly decreased levels of tumor necrosis factor α (TNF-α) and CD8+ and in-creased levels of CD3+, CD4+, and CD4+/CD8+ ratio (P<0.05). The levels of vascular endothelial growth factor (VEGF), nerve growth fac-tor (NGF) and transforming growth factor β1 (TGF-β1) in experimental group were lower than those in control group (P<0.05). The ad-verse reactions in the experimental groupwere significantly lower than those in the control group ( 4.17% vs. 22.92%, P<0.05).Conclu. sion The combination of Qingre Jiedu formula and western medicine treatment can effectively enhance the clinical efficacy of psoria-sis patients of exuberant heat toxin pattern type and reduce serum inflammatory factor levels. |
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