| 徐钰行,弓清梅,朱丽丽.血管生成素 -2在脓毒症致急性肾损伤中的研究进展[J].安徽医药,2026,30(5):864-869. |
| 血管生成素 -2在脓毒症致急性肾损伤中的研究进展 |
| Research progress of angiopoietin-2 in acute kidney injury caused by sepsis |
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| DOI：10.3969/j.issn.1009-6469.2026.05.004 |
| 中文关键词: 脓毒症 血管生成素 -2 血管生成素 急性肾损伤 |
| 英文关键词: Sepsis Angiopoietin-2 Angiopoietin Acute kidney injury |
| 基金项目: |
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| 中文摘要: |
| 脓毒症是临床急危重症，常引发多器官功能衰竭，在其发生发展过程中，肾脏是最常被累及的器官之一。血管生成素(Ang)是一种血管生长因子，包含 Ang1~4四种亚型，其中以 Ang-1与 Ang-2研究最多，最具代表性。该综述从作用机制出发，探讨 Ang-1与 Ang-2两者拮抗作用，并进一步通过 Ang-2在脓毒症致急性肾损伤中的研究，论证其在评估疾病严重程度和临床结局的重要性，以期为疾病的早期治疗提供帮助。 |
| 英文摘要: |
| Sepsis is an acute and severe clinical condition that often leads to multi-organ failure, and the kidney is one of the most fre.quently involved organs in its development. Angiopoietin (Ang) is a vascular growth factor that contains four subtypes of Ang1-4, of which Ang-1 and Ang-2 are the most studied and representative. In this paper, we discuss the antagonistic effects of both Ang-1 and Ang-2 in terms of their mechanisms of action, and further demonstrate the importance of Ang-2 in assessing the severity of the disease and the clinical outcome through the study of Ang-2 in sepsis associated-acute kidney injury, with a view to providing assistance in the early treatment of the disease. |
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