| 王超众,陈鑫,倪杰,等.肿瘤微环境对前列腺癌进展至去势抵抗阶段的影响[J].安徽医药,2026,30(5):870-874. |
| 肿瘤微环境对前列腺癌进展至去势抵抗阶段的影响 |
| Effect of tumor microenvironment on the progression of prostate cancer to castrated resistance stage |
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| DOI：10.3969/j.issn.1009-6469.2026.05.005 |
| 中文关键词: 去势抵抗性前列腺癌 肿瘤微环境 肿瘤免疫 神经周围侵犯 |
| 英文关键词: Castration-resistant prostate cancer Tumor microenvironment Tumor immunity Perineural invasion |
| 基金项目:江苏省卫生健康委科研项目( H2019040) |
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| 中文摘要: |
| 前列腺癌是男性泌尿系统中最常见的恶性肿瘤之一。雄激素剥夺疗法(ADT)是晚期前列腺癌的主要治疗方法，但在治疗过程中几乎所有病人都会发展为去势抵抗性前列腺癌( CRPC)。目前关于 CRPC的形成机制研究较多，其中包括肿瘤微环境( TME)相关机制，均为今后治疗 CRPC提供了重要帮助。现对近年来 TME如何促进前列腺癌进展至 CRPC相关研究进行综述，总结相关机制，给未来进一步研究提供参考。 |
| 英文摘要: |
| Prostate cancer is one of the most common malignant tumors in the male urinary system. Androgen deprivation therapy(ADT) is the mainstay treatment for advanced prostate cancer, but nearly all patients will develop castration-resistant prostate cancer(CRPC) during treatment. At present, there are many studies on the formation of CRPC,including the relevant mechanism of the tumormicroenvironment (TME), which all provide important help for the future treatment of CRPC. This article reviews how TME has promot.ed the progress of prostate cancer to CRPC in recent years, summarizes relevant mechanisms, and provides reference for further re.search in the future. |
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