| 李玉玲,张瑞.IgG4相关自身免疫性胰腺炎的发病机制及治疗进展[J].安徽医药,2026,30(5):874-879. |
| IgG4相关自身免疫性胰腺炎的发病机制及治疗进展 |
| Research advances in the pathogenesis and treatment of type 1 autoimmune pancreatitis |
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| DOI：10.3969/j.issn.1009-6469.2026.05.006 |
| 中文关键词: 自身免疫性胰腺炎 IgG4相关性疾病 皮质类固醇 粒细胞性上皮病变 T淋巴细胞 |
| 英文关键词: Autoimmune pancreatitis IgG4-related disease Corticosteroid Granulocyte epithelial lesion T lymphocyte |
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| 摘要点击次数: 274 |
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| 中文摘要: |
| 自身免疫性胰腺炎( AIP)是一种罕见疾病，以对皮质类固醇的迅速临床反应为特征，根据组织病理学镜下特征将 AIP分为两种不同的类型， 1型自身免疫性胰腺炎(AIP-1)和 2型自身免疫性胰腺炎(AIP-2)前者是 IgG4相关疾病( IgG4-rd)的胰腺表现，血清 IgG4浓度升高，组织学特征为淋巴细胞和浆细胞的大量浸润和簇状纤维化，后，者以粒细胞性上皮病变( GEL)为特征，不伴有 IgG4升高。据调查，在我国， AIP-1较 AIP-2发生率高，尽管基于现有的科学研究对 AIP有了初步的认识，但两者的发病机制仍尚不明确。该综述概述近年来 AIP-1发病机制的相关研究成果，同时也对 AIP-1的现有治疗手段进行分类论述。 |
| 英文摘要: |
| Autoimmune pancreatitis (AIP) is a rare disease, which is characterized by rapid clinical response to corticosteroids. AIP isdivided into two different types based on histopathological characteristics: autoimmune pancreatitis type 1 (AIP-1) and autoimmune pancreatitis type 2 (AIP-2). AIP-1 is a pancreatic manifestation of IgG4-related disease (IgG4-rd) with high serum IgG4 concentrations.Its histological features are extensive infiltration of lymphocytes and plasma cells and clustered fibrosis. AIP-2 is characterized by gran.ulocyte epithelial lesion (GEL) and its serum IgG4 level is low. According to the investigation, in China, the incidence of AIP-1 is high. er than AIP-2. Although based on the existing scientific research, we have a preliminary understanding of AIP, but the pathogenesis ofboth is still unclear. This article mainly summarizes the relevant research results of the pathogenesis of AIP-1 in recent years, and also classifies the existing treatment methods of AIP-1. |
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