| 许彩薇,郭康,张楠,等.血清一氧化氮、 C反应蛋白及白细胞分化抗原 14水平与急性牙髓炎根管治疗术后疼痛及生存质量的相关性[J].安徽医药,2026,30(5):938-941. |
| 血清一氧化氮、 C反应蛋白及白细胞分化抗原 14水平与急性牙髓炎根管治疗术后疼痛及生存质量的相关性 |
| Correlation analysis of serum levels of NO, CRP and CD14 with pain and quality of life in patients with acute pulpitis after root canal treatment |
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| DOI：10.3969/j.issn.1009-6469.2026.05.018 |
| 中文关键词: 牙髓炎 根管治疗 一氧化氮 C反应蛋白 白细胞分化抗原 14 疼痛 生存质量 |
| 英文关键词: Pulpitis Root canal therapy Nitric oxide C-reactive protein Leukocyte differentiation antigen 14 Pain Quali. ty of life |
| 基金项目:河北省医学科学研究课题项目( 20231320) |
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| 中文摘要: |
| 目的分析血清一氧化氮( NO)、 C反应蛋白( CRP)及白细胞分化抗原 14(CD14)水平与急性牙髓炎( AP)病人根管治疗术后疼痛及生存质量的相关性。方法回顾性选取 2021年 12月至 2023年 12月中国人民解放军联勤保障部队第九八〇医院收治的 208例 AP病人纳入疾病组，另选同期 102例健康体检者纳入健康组，检测血清 NO、CRP及 CD14水平。疾病组均行根管治疗术，根据术后疼痛程度划分为轻度、中度与重度疼痛组，根据术后生存质量划分为低质量组、高质量组，分别测定 5组血清 NO、CRP及 CD14水平，分析血清 NO、CRP、CD14水平与疼痛程度、生存质量的相关性。结果疾病组血清 NO［( 7.05±2.01) μmol/L比( 2.58±1.27)μmol/L］、 CRP［( 19.45±6.28)mg/L比( 5.88±1.71)mg/L］、 CD14［( 6.20±1.64)mg/L比( 1.27±0.52)mg/L］水平高于健康组( P<0.05)；术后 7d，轻度、中度与重度疼痛组间血清 NO、CRP、CD14水平差异有统计学意义( P<0.05)；术后 7d，质量组血清 NO［(3.78±1.15)μmol/L比( 2.24±0.96)μmol/L］、 CRP［(14.01±4.12)mg/L比( 8.97±3.14)mg/L］、 CD14［(4.34±0.72)mg/低L比( 3.06±0.43)mg/L］水平高于高质量组( P<0.05)；经 Pearson相关性分析可知，血清 NO、CRP、CD14水平与术后疼痛呈正相关(r=0.77、0.83、0.90，均 P<0.05)，与生存质量呈负相关(r=.0.74、.0.74、.0.86，均 P<0.05)。结论血清 NO、CRP、CD14水平与 AP病人根管治疗术后疼痛呈正相关，与生存质量呈负相关，可通过检测以上因子水平评估病人预后。 |
| 英文摘要: |
| Objective To analyze the correlation between the levels of serum nitric oxide (NO), C-reactive protein (CRP) and leuko. cyte differentiation antigen-14 (CD14) and pain and quality of life in patients with acute pulpitis (AP) after root canal therapy.Meth. ods A retrospective study of 208 AP patients in 980 Hospital of the Joint Logistics Support Force of the People's Liberation Army ofChina from December 2021 to December 2023 were included in the disease group, and another 102 healthy subjects were included inthe healthy group during the same period, serum levels of NO, CRP and CD14 were detected. The disease groups all underwent end.odontics, and were divided into mild, moderate, and severe pain group according to the degree of postoperative pain, and into low-quali. ty group and high-quality group according to the quality of postoperative survival, and the serum NO, CRP, and CD14 levels of the fivegroups were measured respectively to analyze the correlation between serum NO, CRP, and CD14 levels and the degree of pain and thequality of survival.Results The serum NO [(7.05±2.01)μmol/L vs. (2.58±1.27)μmol/L], CRP [(19.45±6.28)mg/L vs. (5.88±1.71)mg/L] and CD14 [(6.20±1.64)mg/L vs. (1.27±0.52)mg/L] level in the disease group were higher than those in the healthy group (P<0.05).There were significant differences in serum levels of NO, CRP and CD14 among mild, moderate and severe pain group at 7 days aftersurgery (P<0.05). On 7th day after operation, the level of serum NO [(3.78±1.15)μmol/L vs. (2.24±0.96)μmol/L], CRP [(14.01±4.12)mg/ L vs. (8.97±3.14)mg/L] and CD14 [(4.34±0.72) mg/L vs. (3.06±0.43) mg/L] in low quality group were higher than those in high quality group (P<0.05). According to Pearson correlation analysis, serum levels of NO, CRP and CD14 were positively correlated with postoper.ative pain (r=0.77, 0.83, 0.90, all P<0.05), and negatively correlated with quality of life (r=.0.74,.0.74,.0.86, all P<0.05).Conclu. sions Serum levels of NO, CRP and CD14 are positively correlated with pain after root canal treatment in AP patients, and negativelycorrelated with quality of life. The prognosis of patients can be evaluated by detecting the levels of these factors. |
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