| 王雷.高氧血症对脓毒症成年病人短期预后的影响[J].安徽医药,2026,30(5):957-962. |
| 高氧血症对脓毒症成年病人短期预后的影响 |
| The impact of hyperoxia on the short-term prognosis of adult patients with sepsis |
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| DOI：10.3969/j.issn.1009-6469.2026.05.022 |
| 中文关键词: 脓毒症 高氧血 倾向评分匹配 机械通气 预后 |
| 英文关键词: Sepsis Hyperxemia Propensity score matching Mechanical ventilation Prognosis |
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| 中文摘要: |
| 目的评估高氧血症对脓毒症病人短期预后的影响。方法筛选 2020年 3月至 2023年 7月在南阳市第一人民医院住院治疗的脓毒症病人 207例作为研究对象。收集病人的临床资料。应用回顾性队列研究方法。根据脓毒症病人入院 48 h内的血氧水平将其分为高氧血症组和非高氧血症组。高氧血症组 124例，非高氧血症组 83例。应用倾向评分匹配( PSM)对两组病人不均衡的协变量进行均衡。对比分析两组病人的短期生存状况。结果非高氧血症组和高氧血症病人，经 PSM倾向性评分匹配，共 77对匹配成功。匹配后两组病人在各协变量的差异全部均衡可比，差异无统计学意义( P>0.05)。即可比性可信。两组急性肾损伤、继发感染、 28 d死亡、 90 d死亡、重症监护室( ICU)内死亡比较，差异无统计学意义( P>0.05)。高氧血症组机械通气( MV)时间［ 9(3，15)d比 6(2，13)d］、 ICU住院时间［ 13(6，25)d比 8(6，20)d］较非高氧血症组长( P<0.05)。并且 PSM匹配前后所有指标表现稳定。结论入院 48 h内的高氧血症对脓毒症病人短期病死率无影响，但可以延长病人的 MV时间和 ICU住院时间。 |
| 英文摘要: |
| Objective To evaluate the impact of hyperoxia on the short-term prognosis of sepsis patients.Methods Two hundred and seven sepsis patients hospitalized in Nanyang First People's Hospital from March 2020 to July 2023 were screened as the studysubjects.Clinical data from patients were collected. Retrospective cohort research methods were applied.Sepsis patients were divided in.to a hyperxemia group and a non hyperxemia group based on their blood oxygen levels within 48 hours of admission.There were 124 pa.tients in the hyperoxia group and 83 patients in the non hyperoxia group.Propensity score matching (PSM) to balance the imbalanced co.variates between two groups of patients was applied.The short-term survival status of two groups of patients was compared and analyzed. Results A total of 77 pairs of non hyperxemia and hyperxemia patients were successfully matched based on PSM propensity score.Af.ter matching, the differences in all covariates between the two groups of patients were balanced and comparable with no statistically sig.nificant differences (P>0.05),indicating that comparability was reliable.There was no significant difference in the acute kidney injury,secondary infection,28 day death,90 day death,and ICU death between two groups(P>0.05).Compared with non hyperxemia group,MV time[9(3,15)d vs. 6(2,13)d] and ICU hospitalization time [13(6,25)d vs. 8(6,20)d] were significantly longer in the hyperoxia group(P< 0.05).Moreover,all indicators showed stable performance before and after PSM matching.Conclusion Hyperxemia within 48 hours of admission does not affect the short-term mortality rate of sepsis patients,but can prolong the duration of MV and ICU hospitalization. |
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