| 张俊杰,及灵霄,李佳琳,等.耳穴埋针联合聚焦超声治疗外阴白色病变的疗效观察[J].安徽医药,2026,30(5):975-978. |
| 耳穴埋针联合聚焦超声治疗外阴白色病变的疗效观察 |
| The curative effect of needle-embidding at otopoints combined with focused ultrasound on white lesions of the external genitalia |
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| DOI：10.3969/j.issn.1009-6469.2026.05.025 |
| 中文关键词: 外阴白色病变 耳穴埋针 聚焦超声 疗效 |
| 英文关键词: Vulvar white lesion Needle-embidding at otopoints Focused ultrasound Curative effect |
| 基金项目:衡水市科技计划项目( 2023014015Z) |
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| 中文摘要: |
| 目的分析耳穴埋针联合聚焦超声治疗外阴白色病变的疗效。方法选取 2021年 12月至 2022年 12月就诊于衡水市妇幼保健院的外阴白色病变女性病人 200例，采用随机数字表法分为超声治疗组( n=100)和联合治疗组( n=100)，超声治疗组采用聚焦超声进行治疗，联合治疗组联合聚焦超声与耳穴埋针法治疗。统计两组病人外阴症状(瘙痒、色素减退、肿痛、弹性降低)改善时间，检测治疗前后血清因子［白细胞介素 -6(IL-6)、 C反应蛋白( CRP)、血管内皮生长因子( VEGF)、内皮素 1(ET-1)］水平，并分析两种治疗方法的疗效，评估病人治疗前后的生活质量［生活质量综合评定问卷( GQOLI-74)］，统计病人的复发率及不良反应情况。结果治疗后，联合治疗组的外阴症状改善时间显著短于超声治疗组，血清 IL-6［(6.62±1.76)ng/L比( 8.27±2.11)ng/L］、 CRP［(7.19±2.05)g/L比( 8.55±2.63)g/L］、ET-1［(75.72±21.07)ng/L比(84.61±25.14)ng/L］水平显著低于超声治疗组， VEGF水平［( 363.94±88.32)ng/L比( 318.53±79.82)ng/L］、 GQOLI-74评分显著高于超声治疗组( P<0.05)；联合治疗组的治疗总有效率显著高于超声治疗组(91%比 79%，χ2=5.65，P<0.05)，复发率显著低于超声治疗组(6%比 17%，χ2=5.94，P<0.05)，两组不良反应发生率差异无统计学意义( 11%比 15%，χ2=0.71，P>0.05)。结论耳穴埋针与聚焦超声联合治疗可有效缓解外阴白色病变病人临床症状，缩短症状改善时间，不仅增加了治疗有效率，还提高了病人生活质量。 |
| 英文摘要: |
| Objective To analyze the curative effect of needle-embidding at otopoints combined with focused ultrasound on white le. sions of the external genitalia. Methods Two hundred female patients with white lesions of the external genitalia, who visitedHengshui Maternal and Child Health Hospital from December 2021 to December 2022, were randomly assigned to an ultrasound thera.py group (n=100) and a combination therapy group (n=100). The ultrasound therapy group received focused ultrasound, while the com.bination therapy group received a combination of focused ultrasound and needle-embidding at otopoints. The improvement time of exter.nal genital symptoms (itching, hypopigmentation, swelling and pain, and decreased elasticity) in two groups was statistically analyzed.Serum factors [interleukin-6 (IL-6), C-reactive protein (CRP), vascular endothelial growth factor (VEGF), and endothelin-1 (ET-1)] lev.els were measured before and after therapy. The efficacies of the two therapies were analyzed. The quality of life before and after thera.py was evaluated using the generic quality of life inventory-74 (GQOLI-74). The recurrence rate and adverse reactions were also statisti. cally analyzed.Results After therapy, the improvement time of external genital symptoms in combination therapy group was obviouslyshorter than that in ultrasound therapy group, and the serum levels of IL-6 [(6.62±1.76) ng/L vs. (8.27±2.11) ng/L], CRP [(7.19±2.05) g/ L vs. (8.55±2.63) g/L], and ET-1 [(75.72±21.07) ng/L vs. (84.61±25.14) ng/L] were significantly lower than those in ultrasound therapy group, and the VEGF level [(363.94±88.32) ng/L vs. (318.53±79.82) ng/L] and GQOLI-74 scores were significantly higher than those in ultrasound therapy group (P<0.05). The total effective rate of combination therapy group was higher than that of ultrasound therapy group (91% vs. 79%,χ2=5.65, P<0.05), and the recurrence rate was lower than that of ultrasound therapy group (6% vs. 17%,χ2=5.94, P <0.05). There was no significant difference in adverse reactions between the two groups (11% vs. 15%,χ2=0.71, P>0.05).Conclusion The combination of needle-embidding at otopoints and focused ultrasound can effectively alleviate the clinical symptoms of patientswith white lesions of the external genitalia, shorten the time for symptom improvement, which not only increases the therapy effective.ness, but also improves the quality of life of patients. |
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